抗Human Prothrombin 抗体:
抗Mouse (Murine) Prothrombin 抗体:
抗Rat (Rattus) Prothrombin 抗体:
Human Polyclonal Prothrombin Primary Antibody for ELISA, IHC - ABIN5693261
Shen, Fang, Lv, Pei, Wang, Jiang, Ding: Heparin impairs angiogenesis through inhibition of microRNA-10b. in The Journal of biological chemistry 2011
Human Polyclonal Prothrombin Primary Antibody for CyTOF, FACS - ABIN4900737
Jesmin, Gando, Zaedi, Prodhan, Sawamura, Miyauchi, Hiroe, Yamaguchi: Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates renal fibrin deposition in a rat model of acute renal failure. in Shock (Augusta, Ga.) 2009
Human Polyclonal Prothrombin Primary Antibody for IF, IHC - ABIN6712793
Ito, Date, Ikegami, Hongo, Fujisaki, Katoh, Yoshino, Anzawa, Nagoshi, Yamashita, Inada, Matsuo, Yamane, Yoshimura: An immunohistochemical analysis of tissue thrombin expression in the human atria. in PLoS ONE 2014
Human Polyclonal Prothrombin Primary Antibody for WB - ABIN515439
Huang, Wu, Tseng, Chen, Hsieh, Chen: Increased prothrombin, apolipoprotein A-IV, and haptoglobin in the cerebrospinal fluid of patients with Huntington's disease. in PLoS ONE 2011
IgG but not IgM antiphosphatidylserine/prothrombin (aPS/PT)antibodies significantly prevailed in antiphospholipid antibody carriers who developed thrombosis.
At low to moderate concentrations, thrombin cleaved PAR2 in a thrombomodulin co-receptor-dependent manner with cleavage efficiency comparable to that of trypsin.
C1-inhibitor can enhance thrombin generation in the presence of thrombomodulin. C1-inhibitor reduces protein C activation by thrombin-thrombomodulin complex.
The Role of Factor V Leiden, Prothrombin G20210A, and MTHFR C677T Mutations in Neonatal Cerebral Sinovenous Thrombosis.
Prothrombin exists mainly in the inactive E* conformational ensemble and conversion to thrombin produces two dominant changes: a progressive shift toward the active E conformational ensemble triggered by removal of the auxiliary domains upon cleavage at R271 and a drastic drop of the rate of ligand dissociation from the active site triggered by cleavage at R320.
uc-AFP, fuc-DCP, and fuc-GPC3 are effective and useful tumor biomarkers. Associated measurement of these biomarkers with canonical discriminant analysis classification is a promising method for the early diagnosis of hepatocellular carcinoma
Meta-analysis of multiple studies finds no association between prothrombin (F2) G20210A polymorphism and risk of retinal vein occlusion.
Under venous flow, fibrinogen continually penetrates the clot, and gamma'-fibrin regulates thrombin in tissue factor driven coagulation.
structural analysis of the mechanism of inhibition of thrombin by NU172
G20210A associated with sickle cell disease in Tunisians
patients who had died during the acute phase of fatal MI more often carried the prothrombin G20210A allele mutation and statistically significant association between prothrombin G20210A and myocardial infarction risk was not observed in the homozygote model.
Serum des-gamma-carboxy-prothrombin a tumor biomarker for diagnosing primary hepatocellular carcinoma. [meta-analysis]
Occlusion of anion-binding exosite 2 in meizothrombin explains its impaired ability to activate factor V.
Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin.
Mutation p.Tyr434His in F2 segregated with thrombosis within the family. Tyr434His in F2 is at the target site of arthropod bleeding toxin.
Thrombin generation increases between the up- and downregulation phases of In Vitro Fertilization (IVF). No correlation between thrombin generation and TFPI was shown during IVF.
Elevated plasma levels of procoagulant factors, such as FVIII or prothrombin, enhanced thrombin generation and reduced the amount of TF required for the initiation of thrombin formation.
When endothelial cells are incubated with antiphospholipid antibodies thrombin generation is increased.
No significant difference in FVL genotype between patients and controls was observed, whereas high frequencies of PRT G20210A, MTHFR C677T and MTHFR A1298C mutations in the Hb S patients
This study proved that Berberine (BBR) is a direct thrombin inhibitor that has activity in inhibiting thrombin-induced platelet aggregation. BBR may be a potential candidate for the development of safe and effective thrombin-inhibiting drugs
Thrombin induced VEGF release from astrocytes require p44/42. Thrombin induced VEGF release from astrocytes is reduced in PAR-1 knockout mice. Thrombin induced p44/42 activation in astrocytes is blocked in PAR-1 knockout mice.
These results suggested that the thrombinstimulated synthesis of IL6 was limited by HSP90 in osteoblasts, and that the effects of HSP90 were exerted at the point between Rhokinase and p38 MAPK.
Platelet derived microparticles formed in sepsis are a potent inducer of thrombin generation via phosphatidylserine exposure, and activation of both the intrinsic and extrinsic pathway of coagulation.
These findings imply that a thrombin-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan plays a protective role during the progression of atherosclerosis in ApoE-deficient mice by inhibiting thrombin generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha-binding and heparin-binding site of thrombin
thrombin/PAR-1 interaction regulated MCP-1, TF, MCSF and IL-6 production.
Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin nanoparticle therapeutics.
Thrombin-PAR1 signaling, via nitric oxide and EPCR, promotes hematopoietic stem cell (HSC) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C epsilon.
thrombin/PAR1 pathway as a novel target for developing therapeutic strategies to restore synaptic function in the acute phase of ischemic stroke.
High Factor IIa expression is associated with multiorgan pathologies in sickle cell disease.
Blockage of thrombin exosites with compounds specific for exosite I (hirudin and HD1 aptamer) or exosite II (heparin and HD22 aptamer) impaired the COMP-thrombin interaction, indicating a 2-site binding mechanism.
Whole blood thrombin generation assay is capable of detecting a prothrombotic phenotype in Bmal1-KO mice.
Fyn, but not Lyn, was required for complete Pyk2 phosphorylation by thrombin.
Thrombin cleavage of osteopontin disrupts a pro-chemotactic sequence for dendritic cells, which is compensated by the release of its pro-chemotactic C-terminal fragment.
The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth.
Influenza virus H1N1 activates platelets through FcgammaRIIA signaling and thrombin generation.
the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.
novel pyranosic sulfated arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated polysaccharides and glycosaminoglycans
Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.
the signaling pathways of MAPK, MSK1, and NF-kappaB play important roles in thrombin-induced iNOS expression in alveolar macrophages
High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.
Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1) and thereby increasing the sensitivity of the myofilament to Ca(2+).
kinetic and structural analysis of interactions between thrombin and the Factor XIII activation peptide
analysis of staphylocoagulase-mediated bovine prothrombin activation
thrombin and factor Xa diffusion along the heparin molecule explains the effects of extended heparin chain lengths
A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.
Thrombomoduln not only binds to HMGB1 but also aids the proteolytic cleavage of HMGB1 by thrombin.
Examination of a dipalmitoylphosphatidylcholine membrane-bound prothrombin 1 fragment reveals another well-defined carboxyglutamic acid (Gla domain)-binding site for phosphatidylserine.
These studies illustrate that GpIbalpha and gamma' target thrombin binding sites with similar consequences on thrombin dynamics, albeit with differing structural features.
ERK-dependent IKKalpha/beta/NF-kappaB signaling pathway plays an important role in thrombin-induced COX-2 expression in human lung fibroblasts.
Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding
The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.
thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII and by receptor-mediated up-regulation of factor XIII synthesis
In conclusion, thrombin activates pro-MMP-2 in the absence of elevated pro-MMP-2 expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2
Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
prepro-coagulation factor II
, prothrombin B-chain
, serine protease
, coagulation factor 2