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抗Human Prothrombin 抗体:
抗Mouse (Murine) Prothrombin 抗体:
抗Rat (Rattus) Prothrombin 抗体:
Human Monoclonal Prothrombin Primary Antibody for ELISA, WB - ABIN2192473
Yin, Wright, Wall, Grammas: Brain endothelial cells synthesize neurotoxic thrombin in Alzheimer's disease. in The American journal of pathology 2010
Show all 2 Pubmed References
Human Polyclonal Prothrombin Primary Antibody for IHC, ELISA - ABIN1583288
Fritze, Zhang, Li, Chai, Mulholland: Thrombin mediates vagal apoptosis and dysfunction in inflammatory bowel disease. in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2014
Human Polyclonal Prothrombin Primary Antibody for CyTOF, FACS - ABIN4900737
Jesmin, Gando, Zaedi, Prodhan, Sawamura, Miyauchi, Hiroe, Yamaguchi: Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates renal fibrin deposition in a rat model of acute renal failure. in Shock (Augusta, Ga.) 2009
Human Polyclonal Prothrombin Primary Antibody for WB - ABIN515439
Huang, Wu, Tseng, Chen, Hsieh, Chen: Increased prothrombin, apolipoprotein A-IV, and haptoglobin in the cerebrospinal fluid of patients with Huntington's disease. in PLoS ONE 2011
These findings suggest that contraction-dependent TGF-beta (显示 TGFB1 抗体) activation could be a mechanism by which thrombin leads to the development of asthmatic airway remodeling.
Case Report: Paradoxical bleeding and thrombotic episodes of dysprothrombinaemia due to a homozygous Arg382His mutation I prothrombin.
PARP-1 (显示 PARP1 抗体) activates prothrombin gene transcription and that the excessive prothrombin gene transcription induces des (显示 DES 抗体)-gamma-carboxy prothrombin (DCP (显示 ACE 抗体)) production in DCP (显示 ACE 抗体)-producing hepatocellular carcinoma cells.
the routine screening of patients with NAIS for F5 G1691A, F2 G20210A and MTHFR (显示 MTHFR 抗体) C677T gene mutations might not be justified, and additional prothrombotic mechanisms should be considered.
Although rare, the prothrombin Belgrade mutation represents strong thrombophilia with early onset of thrombosis in a large Serbian pedigree
There were no significant differences in factor V and factor II genotypes between infertile men and normal controls.
histone H4 has a rapid and drastic inhibitory effect on prothrombin activation by prothrombinase (显示 F10 抗体) that is likely to dominate pathophysiology
prothrombotic mutations in factor V Leiden (显示 F5 抗体) and prothrombin as well as older age are risk factors for venous thrombosis
p300 (显示 EP300 抗体) inhibition attenuates both thrombin induced-CCL2 (显示 CCL2 抗体) expression and histone H3 (显示 HIST3H3 抗体) and H4 acetylation in HLFs, suggesting that p300 (显示 EP300 抗体) is involved in thrombin-induced CCL2 (显示 CCL2 抗体) expression via hyperacetylating histone H3 (显示 HIST3H3 抗体) and H4.
p300 (显示 EP300 抗体)-dependent histone H3 (显示 HIST3H3 抗体) acetylation and C/EBPbeta (显示 CEBPB 抗体)-regulated IKKbeta (显示 IKBKB 抗体) expression contribute to thrombin-induced IL-8/CXCL8 (显示 IL8 抗体) expression in human lung epithelial cells.
Platelet derived microparticles formed in sepsis are a potent inducer of thrombin generation via phosphatidylserine exposure, and activation of both the intrinsic and extrinsic pathway of coagulation.
These findings imply that a thrombin-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan (显示 BGN 抗体) plays a protective role during the progression of atherosclerosis in ApoE (显示 APOE 抗体)-deficient mice by inhibiting thrombin generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (显示 GP1BA 抗体)-binding and heparin-binding site of thrombin
thrombin/PAR-1 (显示 MARK2 抗体) interaction regulated MCP-1 (显示 CPT1B 抗体), TF, MCSF (显示 CSF1 抗体) and IL-6 (显示 IL6 抗体) production.
Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (显示 SERPINC1 抗体) nanoparticle therapeutics.
Thrombin-PAR1 (显示 F2R 抗体) signaling, via nitric oxide and EPCR (显示 PROCR 抗体), promotes hematopoietic stem cell (HSC (显示 FUT1 抗体)) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 (显示 CDC25C 抗体) and Ras-associating domains of phospholipase C epsilon (显示 PLCE1 抗体).
the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.
novel pyranosic sulfated (显示 SULF1 抗体) arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated (显示 SULF1 抗体) polysaccharides and glycosaminoglycans
Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.
the signaling pathways of MAPK (显示 MAPK1 抗体), MSK1 (显示 RPS6KA5 抗体), and NF-kappaB (显示 NFKB1 抗体) play important roles in thrombin-induced iNOS (显示 NOS2 抗体) expression in alveolar macrophages
High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.
Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (显示 F2R 抗体)) and thereby increasing the sensitivity of the myofilament to Ca(2 (显示 CA2 抗体)+).
kinetic and structural analysis of interactions between thrombin and the Factor XIII (显示 UGDH 抗体) activation peptide
analysis of staphylocoagulase-mediated bovine prothrombin activation
thrombin and factor Xa (显示 F10 抗体) diffusion along the heparin molecule explains the effects of extended heparin chain lengths
A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.
Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding
The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.
thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (显示 UGDH 抗体) and by receptor-mediated up-regulation of factor XIII (显示 UGDH 抗体) synthesis
In conclusion, thrombin activates pro-MMP-2 (显示 MMP2 抗体) in the absence of elevated pro-MMP-2 (显示 MMP2 抗体) expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2 (显示 MMP2 抗体)
Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1 (显示 F2R 抗体), RhoA (显示 RHOA 抗体), and myocardin (显示 MYOCD 抗体).
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
prepro-coagulation factor II
, prothrombin B-chain
, serine protease
, coagulation factor 2