蛋白简介

This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene.

Alternative names and synonyms associated with Complement Factor I (CFI)

• complement factor I S homeolog (cfi.S) 抗体
• complement factor I L homeolog (cfi.L) 抗体
• complement factor I (CFI) 抗体
• complement factor I (cfi) 抗体
• complement component factor i (Cfi) 抗体
• 显示所有的基因名称
• complement factor I (Cfi) 抗体

• AHUS3 抗体
• C3b-INA 抗体
• c3bc4bi 抗体
• C3BINA 抗体
• CFI 抗体
• 显示所有的同义词和别名
• factor I 抗体
• FI 抗体
• gb:ai721528 抗体
• IF 抗体
• KAF 抗体
• MGC53615 抗体

Protein level used designations for anti-Complement Factor I (CFI) 抗体

complement factor I , I factor (complement) , complement factor 1 , C3B/C4B inactivator , C3b-inactivator , Konglutinogen-activating factor , complement component I , complement control protein factor I , complement factor I heavy chain , light chain of factor I , complement component 1