Complement Factor I 产品
(Complement Factor I (CFI))
Categories
This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene. [provided by RefSeq, Jul 2008].
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Featured Complement Factor I Categories
Complement Factor I 抗体
High quality antibodies with extensive validation data.
Complement Factor I ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Complement Factor I 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Complement Factor I 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7444067
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7443707
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN516816
Quantity
100 μg
Datasheet
Datasheet
Recommended Complement Factor I ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
Cat. No.
ABIN6955036
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966038
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962758
Quantity
96 tests
Datasheet
Datasheet
Recommended Complement Factor I 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7274339
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1349215
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3091355
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our Complement Factor I Products
: "A monoclonal antibody targeting amyloid β (Aβ) restores complement factor I bioactivity: Potential implications in age-related macular degeneration and Alzheimer's disease." in: PLoS ONE, Vol. 13, Issue 5, pp. e0195751, (2018) (PubMed).: "Thrombotic microangiopathy without renal involvement: two novel mutations in complement-regulator genes." in: Journal of thrombosis and haemostasis : JTH, Vol. 14, Issue 2, pp. 340-5, (2016) (PubMed).
: "Atypical hemolytic uremic syndrome: Korean pediatric series." in: Pediatrics international : official journal of the Japan Pediatric Society, Vol. 57, Issue 3, pp. 431-8, (2015) (PubMed).
: "Mutations in complement factor I predispose to development of atypical hemolytic uremic syndrome." in: Journal of the American Society of Nephrology : JASN, Vol. 16, Issue 7, pp. 2150-5, (2005) (PubMed).
: "Atypical haemolytic uraemic syndrome and mutations in complement regulator genes." in: Springer seminars in immunopathology, Vol. 27, Issue 3, pp. 359-74, (2005) (PubMed).
: "Enrichment of early fetal-liver hemopoietic stem cells of the rat using monoclonal antibodies against the transferrin receptor, Thy-1, and MRC-OX82." in: Developmental immunology, Vol. 4, Issue 4, pp. 235-46, (1996) (PubMed).
Synonyms and alternative names related to Complement Factor I
complement factor I S homeolog (cfi.S), complement factor I L homeolog (cfi.L), complement factor I (CFI), complement factor I (cfi), complement component factor i (Cfi), complement factor I (Cfi), ahus3, AHUS3, c3b-ina, C3b-INA, c3bc4bi, c3bina, C3BINA, cfi, Cfi, CFI, factor I, FI, gb:ai721528, IF, kaf, KAF, MGC53615Protein level used designations for Complement Factor I
- complement factor I
- I factor (complement)
- complement factor 1
- C3B/C4B inactivator
- C3b-inactivator
- Konglutinogen-activating factor
- complement component I
- complement control protein factor I
- complement factor I heavy chain
- light chain of factor I
- complement component 1
您还需要查找其他产品吗？
- Complement Factor H
- Complement Factor Bb
- Complement Factor B
- Complement Component C9b
- Complement C8
- Complement C5b
- Complement C5 Convertase
- Complement C4d
- Complement C4c
- Complement C4
- Complement C3d
- Complement C3c
- Complement C3b
- Complement C3 Convertase
- Complement C2
- Complement C1
- COMP
- COMMD9
- COMMD8
- COMMD7
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