C4B 蛋白

蛋白简介

This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.

Alternative names and synonyms associated with C4B (C4b)

• complement C4B (Chido blood group) (C4B) 抗体
• complement component 4 (c4) 抗体
• complement C4-B (LOC462577) 抗体
• complement component 4B (Chido blood group) (C4B) 抗体
• complement component 4A (Rodgers blood group) (C4a) 抗体
• 显示所有的基因名称
• complement component 4B (Chido blood group) (C4b) 抗体
• complement C4B (Chido blood group) (C4b) 抗体

• C4 抗体
• C4-2 抗体
• C4B 抗体
• C4B1 抗体
• C4B2 抗体
• 显示所有的同义词和别名
• C4B3 抗体
• C4B5 抗体
• C4B12 抗体
• C4BD 抗体
• C4B_2 抗体
• C4F 抗体
• C4l 抗体
• CH 抗体
• CO4 抗体
• CPAMD3 抗体
• DKFZP469I0332 抗体
• Slp 抗体
• Ss 抗体
• wu:fi14a03 抗体

Protein level used designations for Complement Component C4b 蛋白 (C4b)

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3 , Chido form of C4 , basic complement C4 , complement C4-B , complement C4B1a , complement component 4A , complement component 4B , complement component 4B (Chido blood group) , sex-limited protein , complement component 4 (within H-2S) , complement component 4B (Childo blood group) , complement C4-like protein , complement component 4, gene 2