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C4B 产品

(Complement Component C4b (C4b))
This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [provided by RefSeq, Jul 2008].

antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Featured C4B Categories

C4B 抗体

High quality antibodies with extensive validation data.

C4B ELISA试剂盒

Reliable ELISA kits for a wide range of species.

C4B 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended C4B 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7433423
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (4)
Cat. No. ABIN7433420
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (3)
Cat. No. ABIN513870
Quantity 100 μg
Datasheet Datasheet

Recommended C4B ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6955023
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955024
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6973596
Quantity 96 tests
Datasheet Datasheet

Recommended C4B 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122473
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1347540
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1347538
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our C4B Products

Arya, Emri, Synowsky, Shirran, Barzegar-Befroei, Peto, Botting, Lengyel, Stewart: "Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration." in: Experimental eye research, Vol. 172, pp. 21-29, (2018) (PubMed).

Miyahara, Khattar, Schroder, Mierzejewska, Deng, Han, Hancock, Chen, Stepkowski: "Anti-TCRβ mAb induces long-term allograft survival by reducing antigen-reactive T cells and sparing regulatory T cells." in: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 12, Issue 6, pp. 1409-18, (2012) (PubMed).

Murata, Fox-Talbot, Qian, Takahashi, Stahl, Baldwin, Wasowska: "Synergistic deposition of C4d by complement-activating and non-activating antibodies in cardiac transplants." in: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 7, Issue 11, pp. 2605-14, (2007) (PubMed).

Zhang, Kirken, Furian, Janczewska, Qu, Hancock, Wang, Tejpal, Kerman, Kahan, Stepkowski: "Allograft rejection requires STAT5a/b-regulated antiapoptotic activity in T cells but not B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 1, pp. 128-37, (2005) (PubMed).

Gadjeva, Verschoor, Brockman, Jezak, Shen, Knipe, Carroll: "Macrophage-derived complement component C4 can restore humoral immunity in C4-deficient mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 10, pp. 5489-95, (2002) (PubMed).

Paul, Pozdnyakova, Mitchell, Carroll: "Anti-DNA autoreactivity in C4-deficient mice." in: European journal of immunology, Vol. 32, Issue 9, pp. 2672-9, (2002) (PubMed).

Kremmer, Thierfelder, Felber, Hoffmann-Fezer, Wasiliu: "Monoclonal antibodies to complement components without the need of their prior purification. II. Antibodies to mouse C3 and C4." in: Hybridoma, Vol. 9, Issue 4, pp. 309-17, (1990) (PubMed).

Synonyms and alternative names related to C4B

complement C4B (Chido blood group) (C4B), complement C4A (Rodgers blood group) (C4A), complement component 4 (c4), complement C4-B (LOC462577), complement component 4B (Chido blood group) (C4B), complement component 4A (Rodgers blood group) (C4a), complement component 4B (Chido blood group) (C4b), complement C4B (Chido blood group) (C4b), C4, C4-2, C4A2, C4A3, C4A4, C4A6, C4AD, C4B, C4B1, C4B2, C4B3, C4B5, C4B12, C4BD, C4B_2, C4F, C4l, C4S, CH, CO4, CPAMD2, CPAMD3, DKFZP469I0332, RG, Slp, Ss, wu:fi14a03

Protein level used designations for C4B

  • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3
  • Chido form of C4
  • basic complement C4
  • complement C4-B
  • complement C4B1a
  • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2
  • C4A anaphylatoxin
  • Rodgers form of C4
  • acidic C4
  • acidic complement C4
  • complement C4-A
  • complement component 4A
  • complement component 4B
  • complement component 4B (Chido blood group)
  • sex-limited protein
  • complement component 4 (within H-2S)
  • complement component 4B (Childo blood group)
  • complement C4-like protein
  • complement component 4, gene 2
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