Claspin 抗体
(Claspin (CLSPN))
The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
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Latest Publications for our Claspin 抗体
: "Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 19, pp. 7344-9, (2012) (PubMed).: "Claspin as a biomarker of human papillomavirus-related high grade lesions of uterine cervix." in: Journal of translational medicine, Vol. 10, pp. 132, (2012) (PubMed).
: "USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation." in: Human molecular genetics, Vol. 20, Issue 11, pp. 2171-81, (2011) (PubMed).
: "ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells." in: Human molecular genetics, Vol. 19, Issue 9, pp. 1690-701, (2010) (PubMed).
: "NK cells recognize and kill human glioblastoma cells with stem cell-like properties." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 6, pp. 3530-9, (2009) (PubMed).
: "Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways." in: Molecular biology of the cell, Vol. 20, Issue 14, pp. 3305-16, (2009) (PubMed).
: "Loss of CHK1 function impedes DNA damage-induced FANCD2 monoubiquitination but normalizes the abnormal G2 arrest in Fanconi anemia." in: Human molecular genetics, Vol. 17, Issue 5, pp. 679-89, (2008) (PubMed).
: "Chk1 and Claspin potentiate PCNA ubiquitination." in: Genes & development, Vol. 22, Issue 9, pp. 1147-52, (2008) (PubMed).
: "Phosphatase type 2A-dependent and -independent pathways for ATR phosphorylation of Chk1." in: The Journal of biological chemistry, Vol. 282, Issue 10, pp. 7287-98, (2007) (PubMed).
: "Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint." in: The Journal of biological chemistry, Vol. 282, Issue 4, pp. 2729-40, (2007) (PubMed).
Aliases for Claspin 抗体
claspin (Clspn) 抗体claspin (CLSPN) 抗体
claspin (clspn) 抗体
claspin S homeolog (clspn.S) 抗体
B130025E01 抗体
C85083 抗体
CLSPN 抗体
E130314M08Rik 抗体
xClaspin 抗体
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