(Cbp/p300-Interacting Transactivator, with Glu/Asp-Rich Carboxy-terminal Domain, 4 (CITED4))
The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011].
Fox, Bragança, Turley, Campo, Han, Gatter, Bhattacharya, Harris: "CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha." in: Cancer research, Vol. 64, Issue 17, pp. 6075-81, (2004) (PubMed).
Aliases for CITED4 抗体
similar to Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal (CITED4) 抗体 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 (CITED4) 抗体 Cbp/p300-interacting transactivator, with Glu/Asp rich carboxy-terminal domain, 4 (cited4) 抗体 Cbp/p300-interacting transactivator, with Glu/Asp rich carboxy-terminal domain, 4 L homeolog (cited4.L) 抗体 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 (Cited4) 抗体 cCITED3 抗体 CITED3 抗体 CITED4 抗体 MRG-2 抗体 Mrg2 抗体