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Checkpoint with Forkhead and Ring Finger Domains 抗体

(Checkpoint with Forkhead and Ring Finger Domains (CHFR))
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress (By similarity).
CHFR 抗体  (AA 1-652) CHFR 抗体  (AA 1-652) CHFR 抗体 (AA 1-652) (ABIN565913)

CHFR 适用: 人 ELISA, WB, IHC (p), RNAi 宿主: 小鼠 Monoclonal 1H3-A12 unconjugated

CHFR 抗体  (AA 141-422) CHFR 抗体  (AA 141-422) CHFR 抗体 (AA 141-422) (ABIN7151005)

CHFR 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated

CHFR 抗体  (AA 136-194) CHFR 抗体  (AA 136-194) CHFR 抗体 (AA 136-194) (ABIN527639)

CHFR 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2B11 unconjugated

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Find Checkpoint with Forkhead and Ring Finger Domains 抗体 for a variety of species such as anti-Human Checkpoint with Forkhead and Ring Finger Domains, anti-Mouse Checkpoint with Forkhead and Ring Finger Domains, anti-Rat Checkpoint with Forkhead and Ring Finger Domains. The species listed below are among those available. Click on a link to go to the corresponding products.

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Popular Checkpoint with Forkhead and Ring Finger Domains 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB, IHC (p), RNAi
Validations
  • (7)
  • (6)
Cat. No. ABIN565913
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IHC
Validations
  • (3)
Cat. No. ABIN7151005
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (3)
Cat. No. ABIN527639
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, WB, ICC, IF
Validations
  • (3)
Cat. No. ABIN6259505
Quantity 100 μL
Datasheet Datasheet
Reactivity Guinea Pig, Human, Monkey, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application WB, IHC, IHC (p)
Validations
  • (2)
Cat. No. ABIN6747082
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN2855892
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN7003440
Quantity 20 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN184918
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN6138525
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application WB, IHC
Validations
  • (2)
Cat. No. ABIN2774757
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
Cat. No. ABIN706211
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN7151008
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN7151006
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, WB
Validations
Cat. No. ABIN6286821
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application
Validations
Cat. No. ABIN7151007
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Checkpoint with Forkhead and Ring Finger Domains 抗体

Fujita, Yamamoto, Imamura, Nakamura, Maehara, Tsuneyoshi, Oda: "Expression level of the mitotic checkpoint protein and G2-M cell cycle regulators and prognosis in gastrointestinal stromal tumors in the stomach." in: Virchows Archiv : an international journal of pathology, Vol. 460, Issue 2, pp. 163-9, (2012) (PubMed).

Kashima, Idogawa, Mita, Shitashige, Yamada, Ogi, Suzuki, Toyota, Ariga, Sasaki, Tokino: "CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation." in: The Journal of biological chemistry, Vol. 287, Issue 16, pp. 12975-84, (2012) (PubMed).

Hu, Huang, Sun, Wu, Xu, Yin, Chen, Jiang, Shen: "Pathobiologic implications of methylation and expression status of Runx3 and CHFR genes in gastric cancer." in: Medical oncology (Northwood, London, England), Vol. 28, Issue 2, pp. 447-54, (2011) (PubMed).

Privette, Weier, Nguyen, Yu, Petty: "Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint." in: Neoplasia (New York, N.Y.), Vol. 10, Issue 7, pp. 643-52, (2008) (PubMed).

Gao, Xin, Zhang, Zhou: "Mechanism and pathobiologic implications of CHFR promoter methylation in gastric carcinoma." in: World journal of gastroenterology : WJG, Vol. 14, Issue 32, pp. 5000-7, (2008) (PubMed).

Milne, Sitarz, Carvalho, Polak, Ligtenberg, Pauwels, Offerhaus, Weterman: "Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis." in: Human pathology, Vol. 38, Issue 6, pp. 903-13, (2007) (PubMed).

Privette, González, Ding, Kleer, Petty: "Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppression." in: Cancer research, Vol. 67, Issue 13, pp. 6064-74, (2007) (PubMed).

Scolnick, Halazonetis: "Chfr defines a mitotic stress checkpoint that delays entry into metaphase." in: Nature, Vol. 406, Issue 6794, pp. 430-5, (2000) (PubMed).

Aliases for Checkpoint with Forkhead and Ring Finger Domains 抗体

checkpoint with forkhead and ring finger domains (CHFR) 抗体
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase (chfr) 抗体
checkpoint with forkhead and ring finger domains (Chfr) 抗体
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase L homeolog (chfr.L) 抗体
5730484M20Rik 抗体
C230082M18 抗体
CHFR 抗体
fc43f10 抗体
RNF116 抗体
rnf116 抗体
RNF196 抗体
rnf196 抗体
si:dkey-69h6.7 抗体
wu:fc43f10 抗体
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