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CHFR 抗体 (AA 141-422)

CHFR 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7151005
发货至: 中国
  • 抗原 See all CHFR 抗体
    CHFR (Checkpoint with Forkhead and Ring Finger Domains (CHFR))
    抗原表位
    • 8
    • 6
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 141-422
    适用
    • 44
    • 13
    • 12
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 40
    • 3
    • 1
    克隆类型
    • 41
    • 3
    多克隆
    标记
    • 17
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This CHFR antibody is un-conjugated
    应用范围
    • 25
    • 23
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
    交叉反应
    人, 小鼠
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human E3 ubiquitin-protein ligase CHFR protein (141-422AA)
    亚型
    IgG
    Top Product
    Discover our top product CHFR Primary Antibody
  • 应用备注
    Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    CHFR (Checkpoint with Forkhead and Ring Finger Domains (CHFR))
    别名
    CHFR (CHFR 产品)
    别名
    RNF116 antibody, RNF196 antibody, CHFR antibody, fc43f10 antibody, si:dkey-69h6.7 antibody, wu:fc43f10 antibody, rnf116 antibody, rnf196 antibody, 5730484M20Rik antibody, C230082M18 antibody, checkpoint with forkhead and ring finger domains antibody, checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase antibody, checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase L homeolog antibody, CHFR antibody, chfr antibody, Chfr antibody, chfr.L antibody
    背景

    Background: E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the \\\'Lys-48\\\'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of \\\'Lys-63\\\'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at \\\'Lys-63\\\' are usually not targeted for degradation, but are rather involved in signaling cellular stress.

    Aliases: Checkpoint with forkhead and ring finger domains antibody, Checkpoint with forkhead and RING finger domains protein antibody, Chfr antibody, CHFR_HUMAN antibody, E3 ubiquitin protein ligase CHFR antibody, E3 ubiquitin-protein ligase CHFR antibody, EC 6.3.2. antibody, FLJ10796 antibody, FLJ33629 antibody, RING finger protein 196 antibody, RNF 116 antibody, RNF 196 antibody, RNF116 antibody, RNF196 antibody, Ubiquitin ligase protein antibody

    UniProt
    Q96EP1
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