This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine, and is truncated on both termini from the proprotein. [provided by RefSeq, Dec 2008].
Jaworek, Szklarczyk, Kot, Góralska, Jaworek, Bonior, Leja-Szpak, Nawrot-Porąbka, Link-Lenczowski, Ceranowicz, Galazka, Warzecha, Dembinski, Pierzchalski: "Chemerin alleviates acute pancreatitis in the rat thorough modulation of NF-κB signal." in: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], Vol. 19, Issue 3, pp. 401-408, (2019) (PubMed).