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抗Mouse (Murine) HAP1 抗体:
抗Human HAP1 抗体:
抗Rat (Rattus) HAP1 抗体:
Human Monoclonal HAP1 Primary Antibody for ICC, FACS - ABIN259097
Chan, Nasir, Gutekunst, Coleman, Maclean, Maas, Metzler, Gertsenstein, Ross, Nagy, Hayden: Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior. in Human molecular genetics 2002
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Mouse (Murine) Monoclonal HAP1 Primary Antibody for IF, WB - ABIN968461
Gutekunst, Li, Yi, Ferrante, Li, Hersch: The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1998
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Human Polyclonal HAP1 Primary Antibody for IHC, ELISA - ABIN1002402
Borrell-Pagès, Zala, Humbert, Saudou: Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies. in Cellular and molecular life sciences : CMLS 2006
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Monoclonal HAP1 Primary Antibody for IHC (fro), IP - ABIN534035
Gutekunst, Torre, Sheng, Yi, Coleman, Riedel, Bujo: Stigmoid bodies contain type I receptor proteins SorLA/LR11 and sortilin: new perspectives on their function. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2003
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Human Polyclonal HAP1 Primary Antibody for ELISA, WB - ABIN188689
Takeshita, Fujinaga, Zhao, Yanai, Shinoda: Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis. in Human molecular genetics 2006
This study also validated the interaction between HAP1 and Sec23A (显示 SEC23A 抗体) using co-immunoprecipitation experiments with endogenous proteins. This manuscript also reports on the high confidence interacting partners of HAP1 identified by the non-biased approach used in this study, which interestingly, consists of predominantly trafficking-related proteins
findings provide evidence that endogenous APE1 (显示 APEX1 抗体) protects against ischemic infarction in both gray and white matter and facilitates the functional recovery of the central nervous system after mild stroke injury
HAP1 co-localizes with synapsin I (显示 SYN1 抗体) in cortical neurons as discrete puncta
Suppression of Ape1/Ref-1 (显示 APEX1 抗体) redox function leads to an increased cell surface retention of IL-12 (显示 IL12A 抗体) and enhances Th1 (显示 HAND1 抗体) responses.
findings suggest that Hap1 is important for insulin (显示 INS 抗体) secretion of pancreatic beta-cells via regulating the intracellular trafficking and plasma membrane localization of Cav1.2 (显示 CACNA1C 抗体), providing new insight into the mechanisms that regulate insulin (显示 INS 抗体) release from pancreatic beta-cells.
Is closely associated with upregulation of the Ref1 (显示 THOC4 抗体)/Nrf2 (显示 NFE2L2 抗体) signalling pathway.
Results show the stimulatory effect of PARP-1 (显示 PARP1 抗体) on APE1 (显示 APEX1 抗体)-dependent base excision repair (BER). PARP-1 (显示 PARP1 抗体) and APE1 (显示 APEX1 抗体) appear to have a functional interaction in BER since PARP-1 (显示 PARP1 抗体) can stimulate the strand incision activity of APE1 (显示 APEX1 抗体).
Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.
Hap1 interacts with Bcr (显示 BCR 抗体) on microtubules to regulate neuronal differentiation.
increases in APEX1 (显示 APEX1 抗体) level confer protection against the murine paternal age effect, thus highlighting the role of APEX1 (显示 APEX1 抗体) in preserving reproductive health with increasing age and in protection against genotoxin-induced mutagenesis in somatic cells
HAP1 (显示 APEX1 抗体) is expressed in endocrine cells of the human gut (显示 GUSB 抗体).
data fully support that HAP1 (显示 APEX1 抗体) is a GKAP (显示 DLGAP1 抗体), anchoring specifically to the cGMP-dependent protein kinase (显示 CDK7 抗体) isoform Ibeta, and provide further evidence that also PKG (显示 PRKG1 抗体) spatiotemporal signaling is largely controlled by anchoring proteins
HAP1 (显示 APEX1 抗体) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity
Overexpression of HAP1 (显示 APEX1 抗体) reduced in vitro cell growth in breast cancer cell lines.
The results of this study found no association was found between the HAP1 (显示 APEX1 抗体) T441M polymorphism and the age at onset of Huntington's disease .
The results of this study suggested that HAP1 (显示 APEX1 抗体) co-localizes and associates with APP (显示 APP 抗体) in physiological conditions of mouse and human brain.
WT HTT (显示 HTT 抗体) regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1 (显示 PCM1 抗体)).
HAP1 (显示 APEX1 抗体)/stigmoid body interacts with the normal ataxin-3 (显示 ATXN3 抗体) through Josephin (显示 ATXN3 抗体) domain
sortilin (显示 SORT1 抗体) stabilizes the proBDNF.HAP1 complex
ADORA2A (显示 ADORA2A 抗体), but not HAP1 (显示 APEX1 抗体) or OGG1 (显示 OGG1 抗体), may have a role in age at onset in Huntington's disease
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
AP endonuclease 1
, APEX nuclease
, DNA-(apurinic or apyrimidinic site) lyase
, apurinic-apyrimidinic endonuclease 1
, redox factor-1
, huntingtin-associated protein 2
, neuroan 1
, huntingtin-associated protein 1 (neuroan 1)