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抗Human FOXO3 抗体:
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抗Mouse (Murine) FOXO3 抗体:
Human Polyclonal FOXO3 Primary Antibody for IHC - ABIN966151
Smith, Norton, Gorospe, Jiang, Nemoto, Holbrook, Finkel, Kusiak: Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. in The Journal of cell biology 2005
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Human FOXO3 Primary Antibody for IHC - ABIN966150
Essafi, Fernández de Mattos, Hassen, Soeiro, Mufti, Thomas, Medema, Lam: Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. in Oncogene 2005
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Human Polyclonal FOXO3 Primary Antibody for ICC, IF - ABIN152045
Lin, Jan, Kuo: Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine. in Molecular pharmaceutics 2015
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Human Polyclonal FOXO3 Primary Antibody for IF, IHC - ABIN1355835
Lehtinen, Yuan, Boag, Yang, Villén, Becker, DiBacco, de la Iglesia, Gygi, Blackwell, Bonni: A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. in Cell 2006
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Human Polyclonal FOXO3 Primary Antibody for ChIP, ICC - ABIN4312377
Sinanoglu, Yener, Ekici, Midi, Aksungar: The protective effects of spirulina in cyclophosphamide induced nephrotoxicity and urotoxicity in rats. in Urology 2012
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Human Polyclonal FOXO3 Primary Antibody for IF (p), IHC (p) - ABIN731168
Morales, Abrigo, Acuña, Santos, Bader, Brandan, Simon, Olguin, Cabrera, Cabello-Verrugio: Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas. in Disease models & mechanisms 2016
Dog (Canine) Polyclonal FOXO3 Primary Antibody for ELISA, WB - ABIN2473689
Dijkers, Birkenkamp, Lam, Thomas, Lammers, Koenderman, Coffer: FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. in The Journal of cell biology 2002
Human Polyclonal FOXO3 Primary Antibody for ICC, IF - ABIN152044
Yuan, Luo, Liu, Lou: Regulation of SIRT1 activity by genotoxic stress. in Genes & development 2012
Low FOXO3A expression is associated with colorectal cancer.
FoxO3a was overexpressed in 64.71% cases of hepatocellular carcinoma (HCC (显示 FAM126A 抗体)). FoxO3a overexpression was associated with aggressive phenotypes of HCC (显示 FAM126A 抗体), such as histologic grade, stage, and small vessel invasion. FoxO3a overexpression was also correlated with poor disease-free survival. Downregulation of FoxO3a in a HepG2 cell line inhibited cell proliferation and migration.
stable knockdown of FOXO3, NCOA3, and TCF7L2 restored growth in low glucose but reduced MEK/MAPK phosphorylation, reduced anchorage-independent growth, and modulated expressions of GLUT1 and Ras pathway related proteins.
A better understanding of the mechanisms regulating the FOXO3-FOXM1 (显示 FOXM1 抗体) axis, as well as their downstream transcriptional targets and functions, may render these proteins reliable and early diagnostic/prognostic factors as well as crucial therapeutic targets for cancer treatment and importantly, for overcoming chemotherapeutic drug resistance.
the inhibition of miR (显示 MLXIP 抗体)-9 could induce apoptosis in cervical cancer by targeting FOXO3.
Study in three European populations present experimental evidence for a functional link between common intronic variants in FOXO3 and human longevity.
circRNA-FOXO3 expression was decreased in NSCLC cells and tissue samples. It can inhibit the development of NSCLC cells as a ceRNA through sponging miR (显示 MLXIP 抗体)-155 and releasing FOXO3 level.
The protein expression levels of several autophagy makers, such as LC3I, LC3II and Beclin-1 (显示 BECN1 抗体), were higher in FOXO3 plasmid-transfected AGS (显示 JAG1 抗体) cells cultured in an acidic microenvironment than in control cells, while P62 (显示 GTF2H1 抗体) protein expression levels were clearly decreased in FOXO3 plasmid-transfected cells compared with control cells.
Study suggests that miR (显示 MLXIP 抗体)-487a-3p might repress CTLA4 (显示 CTLA4 抗体) and FOXO3 by binding to their 3'UTRs and contribute to the development of T1D.
Findings determined that the crucial regions corresponding to the SP1 (显示 PSG1 抗体) binding sites located between 2,000 and 1,037 bp were essential for FoxO3a transcriptional activity. Furthermore, FoxO3a transcription was upregulated in response to hypoxic and oxidative stress in colorectal tumor cells (CRC (显示 CALR 抗体)), indicating that the interaction between SP1 (显示 PSG1 抗体) and FoxO3a may have important implications in CRC (显示 CALR 抗体) progression.
AIM1 and FOXO3 genes were found to be associated with NBA (number born alive); these genes increase ovarian reproductive capacity and follicle number and decrease gonadotropin levels.
These results indicate that myostatin (显示 MSTN 抗体) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (显示 NR3C1 抗体) binding to its promoter.
In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)
PTEN, FOXO3A and PKB (显示 AKT1 抗体) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.
FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea
by modulating hypoxia-inducible factor activity via up-regulation of VHL (显示 VHL 抗体), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
data suggested that suppressed Sirt3 (显示 SIRT3 抗体)-Foxo3A-Parkin (显示 PARK2 抗体) signaling mediated downregulation of mitophagy may play a vital role in the development of diabetic cardiomyopathy.
AMPK (显示 PRKAA1 抗体) stabilizes FOXO3 and suggest a role in the first initiation step of mitochondrial segregation in muscle cells.
Data indicate a key role of FoxO3a/Zdhhc3 (显示 ZDHHC3 抗体)/GluA1 (显示 GRIA1 抗体) axis in the high-fat diet (HFD)-dependent impairment of cognitive function.
Taken together, these data implicate Foxo3 and its transcriptional targets in outer hair cell survival after noise damage.
These results reveal mechanisms by which FoxO3a promotes host survival during infection with chronic, virulent intracellular bacteria.
findings demonstrate that the mTORC2 (显示 CRTC2 抗体)/AKT (显示 AKT1 抗体)/FOXO3a axis plays a critical role in the anti-proliferative and pro-apoptotic effects of lycopene in UVB-induced photocarcinogenesis.
Melanoma dormancy in a mouse model is linked to GILZ (显示 TSC22D3 抗体)/FOXO3A-dependent quiescence of disseminated stem-like cells
data showed that Klotho (显示 KL 抗体) protects Tac (显示 IL2RA 抗体)-induced oxidative stress by negatively regulating the PI3K/AKT (显示 AKT1 抗体) pathway and subsequently enhancing FoxO3a-mediated MnSOD (显示 SOD2 抗体) expression.
miR (显示 MLXIP 抗体)-34a might suppress the excessive autophagic activity in alveolar type II epithelial AT-II cells via targeting FoxO3 to reduce the damage of LPS (显示 TLR4 抗体)-induced Acute Lung Injury.
PPE effectively attenuated oxidative stress and ototoxicity by regulating FoxO3a, and may thus prove to be beneficial in protecting auditory cells from ototoxic drugs.
NO/protein kinase (显示 CDK7 抗体) G (PKG (显示 PRKG1 抗体))-dependent downregulation of PGC-1 alpha and the ROS (显示 ROS1 抗体) detoxification system in endothelial cells are mediated by the PI3K/Akt (显示 AKT1 抗体) signaling pathway and subsequent inactivation of transcription factor Foxo3a.
FOXO is a key regulator of ROS (显示 ROS1 抗体)-induced apoptosis in mammalian cells.
FOXO1 (显示 FOXO1 抗体), 3, and 4 as well as their upstream regulator, AKT/p-AKT (显示 AKT1 抗体), was examined in rhesus macaque ovaries of three developmental stages: fetal, prepubertal, and adult
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
forkhead box O3A
, forkhead box protein O3
, forkhead homolog (rhabdomyosarcoma) like 1
, forkhead in rhabdomyosarcoma-like 1
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
, forkhead box O3a
, forkhead protein FKHR2
, forkhead box O3A transcription factor
, forkhead box O3
, forkhead box O protein
, forkhead box protein O3-like