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抗Human FOXO3 抗体:
抗Rat (Rattus) FOXO3 抗体:
抗Mouse (Murine) FOXO3 抗体:
Human FOXO3 Primary Antibody for IHC - ABIN966150
Smith, Norton, Gorospe, Jiang, Nemoto, Holbrook, Finkel, Kusiak: Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. in The Journal of cell biology 2005
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Human Polyclonal FOXO3 Primary Antibody for IHC - ABIN966151
Essafi, Fernández de Mattos, Hassen, Soeiro, Mufti, Thomas, Medema, Lam: Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. in Oncogene 2005
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Human Polyclonal FOXO3 Primary Antibody for IF, IHC - ABIN1355835
Lehtinen, Yuan, Boag, Yang, Villén, Becker, DiBacco, de la Iglesia, Gygi, Blackwell, Bonni: A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. in Cell 2006
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Human Polyclonal FOXO3 Primary Antibody for ICC, IF - ABIN152045
Lin, Jan, Kuo: Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine. in Molecular pharmaceutics 2015
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Human Polyclonal FOXO3 Primary Antibody for ChIP, ICC - ABIN4312377
Sinanoglu, Yener, Ekici, Midi, Aksungar: The protective effects of spirulina in cyclophosphamide induced nephrotoxicity and urotoxicity in rats. in Urology 2012
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Human Polyclonal FOXO3 Primary Antibody for IF (p), IHC (p) - ABIN731168
Morales, Abrigo, Acuña, Santos, Bader, Brandan, Simon, Olguin, Cabrera, Cabello-Verrugio: Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas. in Disease models & mechanisms 2016
Dog (Canine) Polyclonal FOXO3 Primary Antibody for ELISA, WB - ABIN2473689
Dijkers, Birkenkamp, Lam, Thomas, Lammers, Koenderman, Coffer: FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. in The Journal of cell biology 2002
Human Polyclonal FOXO3 Primary Antibody for ICC, IF - ABIN152044
Yuan, Luo, Liu, Lou: Regulation of SIRT1 activity by genotoxic stress. in Genes & development 2012
Human Polyclonal FOXO3 Primary Antibody for ELISA, WB - ABIN250244
Brunet, Bonni, Zigmond, Lin, Juo, Hu, Anderson, Arden, Blenis, Greenberg: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. in Cell 1999
Findings determined that the crucial regions corresponding to the SP1 (显示 PSG1 抗体) binding sites located between 2,000 and 1,037 bp were essential for FoxO3a transcriptional activity. Furthermore, FoxO3a transcription was upregulated in response to hypoxic and oxidative stress in colorectal tumor cells (CRC (显示 CALR 抗体)), indicating that the interaction between SP1 (显示 PSG1 抗体) and FoxO3a may have important implications in CRC (显示 CALR 抗体) progression.
FOXO3a expression correlated with adverse clinicopathological features, such as lymph node metastasis, perineural invasion and higher Ki-67 (显示 MKI67 抗体) proliferation index in triple-negative breast cancers.
human FOXO3B locus encodes a bona fide human gene; unlike FOXO3A, FOXO3B is cytosolically localized in both the presence and absence of active Akt (显示 AKT1 抗体)
FoxO3a overexpression increased the transcription and protein expression of Bcl2like protein 11 and cyclindependent kinase inhibitor 1B, and inhibited cyclin D1 (显示 CCND1 抗体) transcription and expression.
miR (显示 MLXIP 抗体)-132 negatively regulates palmitate induced NLRP3 (显示 NLRP3 抗体) inflammasome activation through FOXO3 down-regulation in THP-1 (显示 GLI2 抗体) cells.
these data ascertain the existence of an H2O2-sensitive PRDX1 (显示 PRDX1 抗体)-FOXO3 signaling axis that fine tunes FOXO3 activity toward the transcription of gene targets in response to oxidative stress.
results suggested that SIRT1 (显示 SIRT1 抗体) deficiency in Bladder cancer cells could suppress cell viability by activating antioxidant response and inducing cell cycle arrest possibly via FOXO3a-related pathways.
these results suggest that miR (显示 MLXIP 抗体)-30b plays important roles in kynurenine-induced increase of FOXO3 expression
Authors found that miR (显示 MLXIP 抗体)-629 negatively regulated FOXO3 protein expression and decreased the activity of a luciferase reporter construct containing the FOXO3 3'-untranslated region. These results show that miR (显示 MLXIP 抗体)-629 regulates FOXO3 at the posttranscriptional level, resulting in enhanced cell proliferation and invasion of pancreatic carcinoma.
auranofin could regulate the Her2 (显示 ERBB2 抗体)/Akt (显示 AKT1 抗体)/FOXO3 signaling pathway in SKOV3 cells and be used as a potential antitumor agent considering the expression of MUC4 (显示 MUC4 抗体) in ovarian cancer patients.
These results indicate that myostatin (显示 MSTN 抗体) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (显示 NR3C1 抗体) binding to its promoter.
In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)
PTEN, FOXO3A and PKB (显示 AKT1 抗体) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.
FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea
by modulating hypoxia-inducible factor activity via up-regulation of VHL (显示 VHL 抗体), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
These results reveal mechanisms by which FoxO3a promotes host survival during infection with chronic, virulent intracellular bacteria.
findings demonstrate that the mTORC2 (显示 CRTC2 抗体)/AKT (显示 AKT1 抗体)/FOXO3a axis plays a critical role in the anti-proliferative and pro-apoptotic effects of lycopene in UVB-induced photocarcinogenesis.
Melanoma dormancy in a mouse model is linked to GILZ (显示 TSC22D3 抗体)/FOXO3A-dependent quiescence of disseminated stem-like cells
data showed that Klotho (显示 KL 抗体) protects Tac (显示 IL2RA 抗体)-induced oxidative stress by negatively regulating the PI3K/AKT (显示 AKT1 抗体) pathway and subsequently enhancing FoxO3a-mediated MnSOD (显示 SOD2 抗体) expression.
miR (显示 MLXIP 抗体)-34a might suppress the excessive autophagic activity in alveolar type II epithelial AT-II cells via targeting FoxO3 to reduce the damage of LPS (显示 TLR4 抗体)-induced Acute Lung Injury.
PPE effectively attenuated oxidative stress and ototoxicity by regulating FoxO3a, and may thus prove to be beneficial in protecting auditory cells from ototoxic drugs.
Results show that Foxo3a is depressed in the nucleus while autophagy is impaired, and NLRP3 (显示 NLRP3 抗体) inflammasome is activated in Kupffer cells (KCs). Over-expression of Foxo3a restores autophagy flux and attenuates activation of the NLRP3 (显示 NLRP3 抗体) inflammasome via promoting the transcription of Bim (显示 BCL2L11 抗体).
Data indicate that forkhead box O3 (FoxO3) has a central role in the neuronal reprogramming susceptibility of cells, and the importance of FoxO3 appears to change during development.
These results suggest that lack of FXR (显示 NR1H4 抗体) impaired FoxO3a-mediated autophagy and in turn exacerbated alcohol-induced liver injury
pro-apoptotic role of miR (显示 MLXIP 抗体)-34a in PA-induced cholangiocyte lipoapoptosis in culture and in the liver
NO/protein kinase (显示 CDK7 抗体) G (PKG (显示 PRKG1 抗体))-dependent downregulation of PGC-1 alpha and the ROS (显示 ROS1 抗体) detoxification system in endothelial cells are mediated by the PI3K/Akt (显示 AKT1 抗体) signaling pathway and subsequent inactivation of transcription factor Foxo3a.
FOXO is a key regulator of ROS (显示 ROS1 抗体)-induced apoptosis in mammalian cells.
FOXO1 (显示 FOXO1 抗体), 3, and 4 as well as their upstream regulator, AKT/p-AKT (显示 AKT1 抗体), was examined in rhesus macaque ovaries of three developmental stages: fetal, prepubertal, and adult
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
forkhead box O3A
, forkhead box protein O3
, forkhead homolog (rhabdomyosarcoma) like 1
, forkhead in rhabdomyosarcoma-like 1
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
, forkhead box O3a
, forkhead protein FKHR2
, forkhead box O3A transcription factor
, forkhead box O3
, forkhead box O protein
, forkhead box protein O3-like