The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells\; in exocytosis\; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009].
Yanagi, Reed, Matsuzawa: "PCTAIRE1 regulates p27 stability, apoptosis and tumor growth in malignant melanoma." in: Oncoscience, Vol. 1, Issue 10, pp. 624-33, (2015) (PubMed).
Yanagi, Shi, Aza-Blanc, Reed, Matsuzawa: "PCTAIRE1-knockdown sensitizes cancer cells to TNF family cytokines." in: PLoS ONE, Vol. 10, Issue 3, pp. e0119404, (2015) (PubMed).
Yanagi, Krajewska, Matsuzawa, Reed: "PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells." in: Cancer research, Vol. 74, Issue 20, pp. 5795-807, (2014) (PubMed).
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).