The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008].
Xiao, Li, Larocque, Zhang, Malhotra, Chen, Linhardt, Konermann, Xu: "Dimerization interface of osteoprotegerin revealed by hydrogen-deuterium exchange mass spectrometry." in: The Journal of biological chemistry, Vol. 293, Issue 45, pp. 17523-17535, (2019) (PubMed).
Reutner, Leitner, Müllebner, Ladinig, Essler, Duvigneau, Ritzmann, Steinberger, Saalmüller, Gerner: "CD27 expression discriminates porcine T helper cells with functionally distinct properties." in: Veterinary research, Vol. 44, pp. 18, (2013) (PubMed).
Franzoni, Kurkure, Edgar, Everett, Gerner, Bodman-Smith, Crooke, Graham: "Assessment of the phenotype and functionality of porcine CD8 T cell responses following vaccination with live attenuated classical swine fever virus (CSFV) and virulent CSFV challenge." in: Clinical and vaccine immunology : CVI, Vol. 20, Issue 10, pp. 1604-16, (2013) (PubMed).
Reutner, Leitner, Essler, Witter, Patzl, Steinberger, Saalmüller, Gerner: "Porcine CD27: identification, expression and functional aspects in lymphocyte subsets in swine." in: Developmental and comparative immunology, Vol. 38, Issue 2, pp. 321-31, (2012) (PubMed).
Kara, Sahin, Gunesacar: "Expression of soluble CD27 and interleukins-8 and -10 in B-cell chronic lymphocytic leukemia: correlation with disease stage and prognosis." in: Advances in therapy, Vol. 24, Issue 1, pp. 29-40, (2007) (PubMed).
Yun, Decarlo, Hunter: "Blockade of protease-activated receptors on T cells correlates with altered proteolysis of CD27 by gingipains of Porphyromonas gingivalis." in: Clinical and experimental immunology, Vol. 150, Issue 2, pp. 217-29, (2007) (PubMed).
Vranjkovic, Crawley, Gee, Kumar, Angel: "IL-7 decreases IL-7 receptor alpha (CD127) expression and induces the shedding of CD127 by human CD8+ T cells." in: International immunology, Vol. 19, Issue 12, pp. 1329-39, (2007) (PubMed).