CCL5 蛋白
(Chemokine (C-C Motif) Ligand 5 (CCL5))
This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. [provided by RefSeq, Jul 2008].
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Latest Publications for our CCL5 蛋白
: "CCR1/CCL5 interaction promotes invasion of taxane-resistant PC3 prostate cancer cells by increasing secretion of MMPs 2/9 and by activating ERK and Rac signaling." in: Cytokine, Vol. 64, Issue 1, pp. 251-7, (2014) (PubMed).: "The therapeutic function of the chemokine RANTES on the H22 hepatoma ascites model." in: Molecular and cellular biochemistry, Vol. 367, Issue 1-2, pp. 93-102, (2012) (PubMed).
: "A natural CCL5/RANTES variant antagonist for CCR1 and CCR3." in: Immunogenetics, Vol. 58, Issue 7, pp. 533-41, (2006) (PubMed).
: "Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 19, Issue 3, pp. 227-34, (1999) (PubMed).
: "A human T cell-specific molecule is a member of a new gene family." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 141, Issue 3, pp. 1018-25, (1988) (PubMed).
Aliases for CCL5 蛋白
C-C motif chemokine 5-like (LOC100230935) 蛋白C-C motif chemokine ligand 5 (CCL5) 蛋白
C-C motif chemokine ligand 5 (Ccl5) 蛋白
chemokine (C-C motif) ligand 5 (Ccl5) 蛋白
chemokine (C-C motif) ligand 5 (CCL5) 蛋白
D17S136E 蛋白
eoCP 蛋白
MuRantes 蛋白
Rantes 蛋白
RANTES 蛋白
Scya5 蛋白
SCYA5 蛋白
SIS-delta 蛋白
SISd 蛋白
TCP228 蛋白
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