The heteroteramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (By similarity).
custom-made
CBR4
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
custom-made
CBR4
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
Atsriku, Hoffmann, Moghaddam, Kumar, Surapaneni: "In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism." in: Xenobiotica; the fate of foreign compounds in biological systems, Vol. 45, Issue 6, pp. 465-80, (2015) (PubMed).
Sawamura, Sakurai, Wada, Nishiya, Honda, Kazui, Kurihara, Shinagawa, Izumi: "Bioactivation of loxoprofen to a pharmacologically active metabolite and its disposition kinetics in human skin." in: Biopharmaceutics & drug disposition, (2015) (PubMed).