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Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 蛋白

(Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB))
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. {ECO:0000269|PubMed:10646608, ECO:0000269|PubMed:10646609, ECO:0000269|PubMed:11070165, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:12771181, ECO:0000269|PubMed:15308098}.

7 results :

custom-made CBLB 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7563677
 
custom-made CBLB 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7552901
 
CBLB 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Pubmed 1 reference
产品编号 ABIN1348172
 
CBLB 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
产品编号 ABIN7122186
 
custom-made CBLB 宿主: 小鼠 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, WB, SDS
产品编号 ABIN3134985
 
custom-made CBLB 宿主: 人 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, WB, SDS
产品编号 ABIN3090503
 
CBLB 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
产品编号 ABIN2713255
 
  • 类型 Protein
    • Protein
  • 应用范围
    • ELISA
    • Western Blotting (WB)
    • SDS-PAGE (SDS)
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • Antibody Production (AbP)
    • Standard (STD)
  • 适用
    • Human
    • Mouse
  • 论文引用
  • 图像
  • Carrier free only
  • 抗体来源
    • HEK-293 Cells
    • Cell-free protein synthesis (CFPS)
    • Escherichia coli (E. coli)
    • Wheat germ
  • 抗原表位
    • AA 1-982
    • AA 39-426
  • 标记
    • His tag
    • Strep Tag
    • GST tag
    • Myc-DYKDDDDK Tag
  • 蛋白类型
    • Recombinant
  • Format
    • Liquid
    • Lyophilized
  • Grade
    • custom-made
  • Supplier
    • antibodies-online
    • OriGene

Latest Publications for our Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 蛋白

Gruber, Hinterleitner, Hermann-Kleiter, Meisel, Kleiter, Wang, Viola, Pfeifhofer-Obermair, Baier: "Cbl-b mediates TGF? sensitivity by downregulating inhibitory SMAD7 in primary T cells." in: Journal of molecular cell biology, Vol. 5, Issue 6, pp. 358-68, (2013) (PubMed).

Aliases for Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 蛋白

Cbl proto-oncogene B, E3 ubiquitin protein ligase S homeolog (cblb.S) 蛋白
Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog (cblb.L) 蛋白
Casitas B-lineage lymphoma b (Cblb) 蛋白
Cbl proto-oncogene B (Cblb) 蛋白
Cbl proto-oncogene B (CBLB) 蛋白
AI429560 蛋白
AI851073 蛋白
Cbl-b 蛋白
cblb 蛋白
rnf56 蛋白
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