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Study provides accurate validation of functional CGRP (显示 CALCA 蛋白) receptor expression throughout the brainstem and the spinal cord of non-human primates: several areas in the brainstem were shown to express CLR (显示 DCLK3 蛋白) and RAMP1 mRNA and protein
the cardiovascular response of Ramp1(-/-), Ramp2 (显示 RAMP2 蛋白)(+/-), Ramp3 (显示 RAMP3 蛋白)(-/-), Ramp1(-/-)/Ramp3 (显示 RAMP3 蛋白)(-/-) double-knockout (dKO), and Calcrl (显示 CALCRL 蛋白)(+/-) mice to AM and CGRP (显示 CALCA 蛋白) were compared to wildtype mice.These results suggest that the hypotensive effect of AM is primarily mediated through the CLR (显示 CALCR 蛋白)/RAMP1 heterodimer, but that AM signaling via CLR (显示 CALCR 蛋白)/RAMP2 (显示 RAMP2 蛋白) and CLR (显示 CALCR 蛋白)/RAMP3 (显示 RAMP3 蛋白) also contributes to some hypotensive action.
RAMP1 signaling improves lymphedema and accelerates lymphangiogenesis associated with reduced recruitment of pro-inflammatory macrophages.
RAMP1 exerted mucosal protection in DSS (显示 PMP22 蛋白)-induced colitis via attenuation of recruitment of inflammatory cells and of pro-inflammatory cytokines.
Together, these data indicate that signaling through RAMP1 and CLR (显示 CALCR 蛋白) plays a role in mediating asthma pathology
multiple NKX3.1 (显示 NKX3-1 蛋白) binding sites were found in the RAMP1 locus in human prostate cancer cells and in the normal mouse prostate.
Data indicate that IL-17 (显示 IL17A 蛋白) production is suppressed in RAMP1-deficient mice in the experimental autoimmune encephalomyelitis (EAE) model and RAMP1-deficient mice are completely resistant to EAE.
Data indicate that the lack of an intact CGRP receptor component (显示 CRCP 蛋白) RAMP1 resulted in an increased recruitment and activation of neutrophils.
Data show that mechanical ventilation reduced the expression of receptor activity-modifying protein RAMP3 (显示 RAMP3 蛋白), but not of intermedin (IMD (显示 ADM2 蛋白)), calcitonin receptor-like receptor (CRLR (显示 CALCRL 蛋白)), and RAMP1 and RAMP2 (显示 RAMP2 蛋白).
significantly diminished intestinal peristalsis was observed by the allergy induction in RAMP1-deficient mice compared with WT mice.
These findings suggest that RAMP1 may be a new therapeutic target to regulate CGRP (显示 CALCA 蛋白)-mediated effects during disease including pathophysiological states in which Ang II (显示 AGT 蛋白) plays a major role.
T-A-T RAMP1 gene haplotype might have utility as a genetic marker for Essential Hypertension and that the RAMP1 gene may be associated with increased susceptibility to Essential Hypertension in a Japanese population.
Data suggest CGRP (显示 S100A12 蛋白) receptor (CGRPR (显示 CALCRL 蛋白)) ECL2 (extracellular loop 2 domain) enables interaction with N-terminal residues of CGRP (显示 S100A12 蛋白); this provides evidence for dual involvement of ECL2 in two-domain binding model of CGRP (显示 S100A12 蛋白)/CGRPR (显示 CALCRL 蛋白) interaction; CGRPR (显示 CALCRL 蛋白) is obligate heterodimer of CLR (显示 DCLK3 蛋白)/RAMP1. (CGRP (显示 S100A12 蛋白) = calcitonin gene-related peptide (显示 CALCA 蛋白); CLR (显示 DCLK3 蛋白) = calcitonin receptor-like receptor (显示 CALCRL 蛋白); RAMP1 = receptor [calcitonin (显示 CALCA 蛋白)] activity modifying protein 1)
Evidence that DNA methylation (显示 HELLS 蛋白) at RAMP1 gene promoter plays a role in migraine was described.
RAMP1 rs7590387 has a role in the transformation of episodic migraine into medication overuse headache.
Data suggest that ligand binding of a G protein-coupled receptor (GPCR (显示 TAS1R3 蛋白)) may inform drug development targeting calcitonin receptor-like receptor (CLR (显示 CALCRL 蛋白)):receptor activity-modifying proteins RAMP1/2 complexes.
A novel functional role for RAMP1 in regulation of CaSR (显示 CASR 蛋白) signalling in addition to its known role in receptor trafficking, is reported.
RAMP1 overexpression enhances the promoting effect that exogenous CGRP (显示 S100A12 蛋白) has on osteogenic differentiation
No significant association of the tested SNPs of the RAMP1 gene were found with migraine susceptibility.
CLR (显示 DCLK3 蛋白) and RAMP1 co-localize in the enteric nervous system of human stomach, ileum, and colon, and are in close proximity to their ligands CGRP (显示 S100A12 蛋白) and IMD (显示 ADM2 蛋白)
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.
receptor (calcitonin) activity modifying protein 1
, receptor activity-modifying protein 1
, receptor activity modifying protein 1
, receptor (G protein-coupled) activity modifying protein 1
, CRLR activity-modifying protein 1
, calcitonin receptor-like receptor activity modifying protein 1
, calcitonin-receptor-like receptor activity-modifying protein 1