Caspase 8 抗体
(Caspase 8 (CASP8))
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008].
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209 results
Independently Validated
CASP8
适用: 人
WB, IHC, ELISA, IF
宿主: 兔
Polyclonal
unconjugated
CASP8
适用: 小鼠
WB, IHC, ELISA, ICC, FACS
宿主: 大鼠
Monoclonal
3B10
unconjugated
CASP8
适用: 人, 小鼠, 大鼠
WB, IHC, ELISA, ICC, IF
宿主: 兔
Polyclonal
unconjugated
CASP8
适用: 小鼠
WB, IHC, ELISA, FACS
宿主: 大鼠
Monoclonal
1G12
unconjugated
CASP8
适用: 小鼠
WB, IHC, ICC, IP
宿主: 兔
Polyclonal
unconjugated
CASP8
适用: 小鼠
WB, IHC, ICC, IP
宿主: 兔
Polyclonal
unconjugated
CASP8
适用: 人, 大鼠
WB, IHC, ELISA, ICC, IF
宿主: 兔
Polyclonal
unconjugated
2 references
CASP8
适用: 人
WB, ELISA, IF, IHC (p)
宿主: 兔
Polyclonal
unconjugated
CASP8
适用: 人, 小鼠, 大鼠
WB, IF, IHC (p)
宿主: 小鼠
Monoclonal
2E3
unconjugated
CASP8
适用: 人
WB, FACS
宿主: 小鼠
Monoclonal
550CT8-5-2
unconjugated
CASP8
适用: 人, 小鼠, 猴
WB, FACS
宿主: 小鼠
Monoclonal
90A992
unconjugated
2 images
Latest Publications for our Caspase 8 抗体
: "NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma." in: Molecular neurodegeneration, Vol. 15, Issue 1, pp. 26, (2020) (PubMed).: "The protective role of the MKP-5-JNK/P38 pathway in glucolipotoxicity-induced islet β-cell dysfunction and apoptosis." in: Experimental cell research, Vol. 382, Issue 1, pp. 111467, (2020) (PubMed).
: "Downregulation of METTL14 increases apoptosis and autophagy induced by cisplatin in pancreatic cancer cells." in: The international journal of biochemistry & cell biology, Vol. 122, pp. 105731, (2020) (PubMed).
: "Triggering apoptosis by oroxylin A through caspase-8 activation and p62/SQSTM1 proteolysis." in: Redox biology, Vol. 29, pp. 101392, (2020) (PubMed).
: "Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway." in: Investigational new drugs, Vol. 38, Issue 1, pp. 50-59, (2020) (PubMed).
: "Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke." in: Cell death & disease, Vol. 10, Issue 7, pp. 487, (2020) (PubMed).
: "GL-V9 exerts anti-T cell malignancies effects via promoting lysosome-dependent AKT1 degradation and activating AKT1/FOXO3A/BIM axis." in: Free radical biology & medicine, Vol. 145, pp. 237-249, (2020) (PubMed).
: "Xanthones from the Bark of Garcinia xanthochymus and the Mechanism of Induced Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells via the Mitochondrial Pathway." in: International journal of molecular sciences, Vol. 20, Issue 19, (2020) (PubMed).
: "Histone methyltransferase SETDB1 promotes colorectal cancer proliferation through the STAT1-CCND1/CDK6 axis." in: Carcinogenesis, Vol. 41, Issue 5, pp. 678-688, (2020) (PubMed).
: "Giardia duodenalis induces extrinsic pathway of apoptosis in intestinal epithelial cells through activation of TNFR1 and K63 de-ubiquitination of RIP1 in vitro." in: Microbial pathogenesis, Vol. 149, pp. 104315, (2020) (PubMed).
Aliases for Caspase 8 抗体
caspase 8 L homeolog (casp8.L) 抗体death related ced-3/Nedd2-like protein (LOC661095) 抗体
caspase 8 (CASP8) 抗体
caspase-8 (LOC5563818) 抗体
caspase-8 (casp8) 抗体
caspase-8-like (LOC100222284) 抗体
caspase 8 (Casp8) 抗体
caspase 8, apoptosis-related cysteine peptidase (casp8) 抗体
ALPS2B 抗体
CAP4 抗体
CASP-8 抗体
Casp-8 抗体
casp8 抗体
CASP8 抗体
casp8-A 抗体
caspase-8 抗体
FLICE 抗体
MACH 抗体
Mch5 抗体
MCH5 抗体
xCaspase-8 抗体
zgc:92075 抗体
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