The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008].
Macchi, Kroening, Palacios, Baldassa, Grunewald, Ambrosino, Goetze, Lupas, St Johnston, Kiebler: "Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 23, Issue 13, pp. 5778-88, (2003) (PubMed).
Degot, Régnier, Wendling, Chenard, Rio, Tomasetto: "Metastatic Lymph Node 51, a novel nucleo-cytoplasmic protein overexpressed in breast cancer." in: Oncogene, Vol. 21, Issue 28, pp. 4422-34, (2002) (PubMed).
Aliases for CASC3 抗体
cancer susceptibility 3 (CASC3) 抗体 cancer susceptibility candidate 3 (Casc3) 抗体 cancer susceptibility 3 (Casc3) 抗体 cancer susceptibility 3 (casc3) 抗体 protein CASC3 (casc3) 抗体 cancer susceptibility 3 S homeolog (casc3.S) 抗体 cancer susceptibility candidate 3 (casc3) 抗体 barentsz 抗体 BTZ 抗体 Btz 抗体 btz 抗体 CASC3 抗体 MLN51 抗体 Mln51 抗体 mln51 抗体 StMLN51 抗体 XlMLN51 抗体