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CARD16 产品

(Caspase Recruitment Domain Family, Member 16 (CARD16))

Categories

Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.

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Featured CARD16 Categories

CARD16 抗体

High quality antibodies with extensive validation data.

CARD16 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CARD16 抗体

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Reactivity
Application
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Datasheet
Reactivity Human
Application ELISA, WB, IHC
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  • (2)
Cat. No. ABIN7244684
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB
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  • (2)
Cat. No. ABIN530261
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Reactivity Human
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Cat. No. ABIN566717
Quantity 100 μg
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Recommended CARD16 蛋白

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Datasheet
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Source Wheat germ
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Cat. No. ABIN1348045
Quantity 10 μg
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Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3090483
Quantity 1 mg
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Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN2713162
Quantity 50 μg
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Latest Publications for our CARD16 Products

Druilhe, Srinivasula, Razmara, Ahmad, Alnemri: "Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins." in: Cell death and differentiation, Vol. 8, Issue 6, pp. 649-57, (2001) (PubMed).

Synonyms and alternative names related to CARD16

caspase recruitment domain family member 16 (CARD16), COP, COP1, PSEUDO-ICE

Protein level used designations for CARD16

  • CARD only domain-containing protein 1
  • CARD only protein
  • caspase recruitment domain-containing protein 16
  • caspase-1 dominant-negative inhibitor pseudo-ICE
  • caspase-1 inhibitor COP
  • pseudo interleukin-1 beta converting enzyme
  • pseudo interleukin-1beta converting enzyme
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