(Calcium Channel, Voltage-Dependent, N Type, alpha 1B Subunit (CACNA1B))
The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
Lenkey, Kirizs, Holderith, Máté, Szabó, Vizi, Hájos, Nusser: "Tonic endocannabinoid-mediated modulation of GABA release is independent of the CB1 content of axon terminals." in: Nature communications, Vol. 6, pp. 6557, (2015) (PubMed).
Simen, Lee, Simen, Bindokas, Miller: "The C terminus of the Ca channel alpha1B subunit mediates selective inhibition by G-protein-coupled receptors." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 19, pp. 7587-97, (2001) (PubMed).