Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Lee, Vecchio-Pagán, Sharma, Waheed, Li, Raraigh, Robbins, Han, Franca, Pellicore, Evans, Arcara, Nguyen, Luan, Belchis, Hertecant, Zabner, Sly, Cutting: "Loss of carbonic anhydrase XII function in individuals with elevated sweat chloride concentration and pulmonary airway disease." in: Human molecular genetics, Vol. 25, Issue 10, pp. 1923-1933, (2016) (PubMed).
Vermeulen, Kornegoor, van der Wall, van der Groep, van Diest: "Differential expression of growth factor receptors and membrane-bound tumor markers for imaging in male and female breast cancer." in: PLoS ONE, Vol. 8, Issue 1, pp. e53353, (2013) (PubMed).
Tafreshi, Bui, Bishop, Lloyd, Enkemann, Lopez, Abrahams, Carter, Vagner, Grobmyer, Gobmyer, Gillies, Morse: "Noninvasive detection of breast cancer lymph node metastasis using carbonic anhydrases IX and XII targeted imaging probes." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 1, pp. 207-19, (2012) (PubMed).
Vermeulen, van Brussel, van der Groep, Morsink, Bult, van der Wall, van Diest: "Immunophenotyping invasive breast cancer: paving the road for molecular imaging." in: BMC cancer, Vol. 12, pp. 240, (2012) (PubMed).
Davidson, Stavnes, Holth, Chen, Yang, Shih, Wang: "Gene expression signatures differentiate ovarian/peritoneal serous carcinoma from breast carcinoma in effusions." in: Journal of cellular and molecular medicine, Vol. 15, Issue 3, pp. 535-44, (2011) (PubMed).