This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. Overexpression of the encoded protein results in apoptosis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012].
Heiser, Labi, Erlacher, Villunger: "The Bcl-2 protein family and its role in the development of neoplastic disease." in: Experimental gerontology, Vol. 39, Issue 8, pp. 1125-35, (2004) (PubMed).
Cory, Huang, Adams: "The Bcl-2 family: roles in cell survival and oncogenesis." in: Oncogene, Vol. 22, Issue 53, pp. 8590-607, (2003) (PubMed).
Kataoka, Holler, Micheau, Martinon, Tinel, Hofmann, Tschopp: "Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension." in: The Journal of biological chemistry, Vol. 276, Issue 22, pp. 19548-54, (2001) (PubMed).