B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3\; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011].
Bjørnsen, Thiruchelvam-Kyle, Hoelsbrekken, Henden, Saether, Boysen, Daws, Dissen: "B7H6 is a functional ligand for NKp30 in rat and cattle and determines NKp30 reactivity toward human cancer cell lines." in: European journal of immunology, Vol. 49, Issue 1, pp. 54-65, (2019) (PubMed).
Anft, Netter, Urlaub, Prager, Schaffner, Watzl: "NK cell detachment from target cells is regulated by successful cytotoxicity and influences cytokine production." in: Cellular & molecular immunology, (2019) (PubMed).
Fielding, Weekes, Nobre, Ruckova, Wilkie, Paulo, Chang, Suárez, Davies, Antrobus, Stanton, Aicheler, Nichols, Vojtesek, Trowsdale, Davison, Gygi, Tomasec, Lehner, Wilkinson: "Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation." in: eLife, Vol. 6, (2017) (PubMed).
Charpak-Amikam, Kubsch, Seidel, Oiknine-Djian, Cavaletto, Yamin, Schmiedel, Wolf, Gribaudo, Messerle, Cicin-Sain, Mandelboim: "Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20." in: Scientific reports, Vol. 7, Issue 1, pp. 8661, (2017) (PubMed).