BAG4 抗体
(BCL2-Associated Athanogene 4 (BAG4))
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011].
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Latest Publications for our BAG4 抗体
: "GRP78 Interacting Partner Bag5 Responds to ER Stress and Protects Cardiomyocytes From ER Stress-Induced Apoptosis." in: Journal of cellular biochemistry, Vol. 117, Issue 8, pp. 1813-21, (2016) (PubMed).: "Expression of Bcl-2 and the antiapoptotic BAG family proteins in ovarian cancer." in: Applied immunohistochemistry & molecular morphology : AIMM, Vol. 21, Issue 6, pp. 518-24, (2013) (PubMed).
: "Heat shock protein 70 (Hsp70): membrane location, export and immunological relevance." in: Methods (San Diego, Calif.), Vol. 43, Issue 3, pp. 229-37, (2007) (PubMed).
: "BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 22 Pt 1, pp. 6585-92, (2007) (PubMed).
: "Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells." in: Cancer research, Vol. 65, Issue 12, pp. 5238-47, (2005) (PubMed).
: "Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, and Hsp40: protection against radiation-induced effects and target structure for natural killer cells." in: Cell death and differentiation, Vol. 12, Issue 1, pp. 38-51, (2004) (PubMed).
: "Role of SODD in regulation of tumor necrosis factor responses." in: Molecular and cellular biology, Vol. 23, Issue 11, pp. 4026-33, (2003) (PubMed).
: "Apparently normal tumor necrosis factor receptor 1 signaling in the absence of the silencer of death domains." in: Molecular and cellular biology, Vol. 23, Issue 18, pp. 6609-17, (2003) (PubMed).
Aliases for BAG4 抗体
BCL2 associated athanogene 4 (BAG4) 抗体BCL2-associated athanogene 4 (Bag4) 抗体
BCL2-associated athanogene 4 (bag4) 抗体
BCL-2-associated athanogene 4 (BAG4) 抗体
BCL2 associated athanogene 4 (Bag4) 抗体
2410112I15Rik 抗体
ATBAG4 抗体
BAG-4 抗体
BAG4 抗体
BCL-2-associated athanogene 4 抗体
fd20a04 抗体
si:dkey-220o5.3 抗体
SODD 抗体
wu:fd20a04 抗体
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