BACE1 抗体
(Beta-secretase 1 (BACE1))
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011].
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Latest Publications for our BACE1 抗体
: "Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration." in: Nature communications, Vol. 13, Issue 1, pp. 5308, (2022) (PubMed).: "Extracellular vesicles: where the amyloid precursor protein carboxyl-terminal fragments accumulate and amyloid-β oligomerizes." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 34, Issue 9, pp. 12922-12931, (2021) (PubMed).
: "A pleiotropic role for exosomes loaded with the amyloid β precursor protein carboxyl-terminal fragments in the brain of Down syndrome patients." in: Neurobiology of aging, Vol. 84, pp. 26-32, (2020) (PubMed).
: "NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration." in: Particle and fibre toxicology, Vol. 14, Issue 1, pp. 34, (2018) (PubMed).
: "An Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase Activity." in: PLoS ONE, Vol. 11, Issue 11, pp. e0166415, (2017) (PubMed).
: "Dopamine D2 receptor and β-arrestin 2 mediate Amyloid-β elevation induced by anti-parkinson's disease drugs, levodopa and piribedil, in neuronal cells." in: PLoS ONE, Vol. 12, Issue 3, pp. e0173240, (2017) (PubMed).
: "Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-β Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus." in: Neurochemical research, Vol. 41, Issue 5, pp. 1192-9, (2016) (PubMed).
: "NO2 inhalation promotes Alzheimer's disease-like progression: cyclooxygenase-2-derived prostaglandin E2 modulation and monoacylglycerol lipase inhibition-targeted medication." in: Scientific reports, Vol. 6, pp. 22429, (2016) (PubMed).
: "Osthole decreases beta amyloid levels through up-regulation of miR-107 in Alzheimer's disease." in: Neuropharmacology, Vol. 108, pp. 332-44, (2016) (PubMed).
: "Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1." in: The Journal of biological chemistry, Vol. 291, Issue 5, pp. 2067-79, (2016) (PubMed).
Aliases for BACE1 抗体
beta-secretase 1 (BACE1) 抗体beta-site APP cleaving enzyme 1 (Bace1) 抗体
beta-secretase 1 (Bace1) 抗体
beta-site APP-cleaving enzyme 1 (bace1) 抗体
ASP2 抗体
BACE 抗体
Bace 抗体
BACE1 抗体
C76936 抗体
HSPC104 抗体
MGC145931 抗体
zgc:77409 抗体
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