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ASAP2 蛋白

(ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2))
This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].

5 results :

custom-made ASAP2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7564186
 
custom-made ASAP2 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7552343
 
ASAP2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
产品编号 ABIN1345787
 
custom-made ASAP2 宿主: 小鼠 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, WB, SDS
产品编号 ABIN3135911
 
custom-made ASAP2 宿主: 人 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, WB, SDS
产品编号 ABIN3089284
 
  • 类型 Protein
    • Protein
  • 应用范围
    • ELISA
    • Western Blotting (WB)
    • SDS-PAGE (SDS)
    • Affinity Purification (AP)
    • Antibody Array (AA)
  • 适用
    • Human
    • Mouse
  • 图像
  • Carrier free only
  • 抗体来源
    • Cell-free protein synthesis (CFPS)
    • HEK-293 Cells
    • Wheat germ
  • 抗原表位
    • AA 1-1006
    • AA 1-958
  • 标记
    • His tag
    • Strep Tag
    • GST tag
  • 蛋白类型
    • Recombinant
  • Format
    • Liquid
  • Grade
    • custom-made
  • Supplier
    • antibodies-online

Aliases for ASAP2 蛋白

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (ASAP2) 蛋白
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 L homeolog (asap2.L) 蛋白
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b (asap1b) 蛋白
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (asap2) 蛋白
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (Asap2) 蛋白
6530401G17Rik 蛋白
AMAP2 蛋白
asap2 蛋白
CENTB3 蛋白
DDEF2 蛋白
ddef2 蛋白
Ddef2 蛋白
Gm592 蛋白
Gm1523 蛋白
PAG3 蛋白
PAP 蛋白
Pap-alpha 蛋白
SHAG1 蛋白
si:dkey-37o8.2 蛋白
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