Adipocytes have been studied with increasing intensity as a result of the emergence of obesity as a serious public health problem and the realization that adipose tissue serves as an integrator of various physiological pathways. In particular, their role in calorie storage makes adipocytes well suited to the regulation of energy balance.(1) We differentiate between brown, white and beige adipocytes.
antibodies-online offers an excellent selection of antibodies, kits and tools for the investigation of adipocytes. Below you will find hand-picked, reliable products for some of the important targets.
Markers for beige Adipocytes
The expression of several thermoregulatory genes such as Uncoupling Protein-1 (UCP1), Cell Death-Inducing DFFA-Like Effector A (CIDEA) or Cytochrome C Oxidase Subunit VIIIb (Cox8b) has been employed to evaluate the induction of beige adipocytes in white adipose tissue. In addition, transcripts of several markers (e.g., TBX1, TMEM26, CD137, FGF21, P2RX5, PAT2, CAR4, and CITED1) have been identified that appear to be specific for beige adipocytes.(2)
Product
Reactivity
Clone
Application
Validations
Cat. No.
Quantity
Reactivity
Human, Mouse, Rat
Clone
Application
ELISA, WB, FACS, IHC (p)
Cat. No.
ABIN740445
Quantity
100 μL
Reactivity
Human
Clone
Application
WB, IHC, IF
Cat. No.
ABIN6149883
Quantity
100 μL
Reactivity
Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat
Clone
Application
WB, IHC
Cat. No.
ABIN2777537
Quantity
100 μL
Reactivity
Human
Clone
Application
WB, ELISA, IHC, IF
Cat. No.
ABIN7147273
Quantity
100 μg
Reactivity
Human
Clone
Application
WB, IHC, ELISA
Cat. No.
ABIN7234858
Quantity
200 μL
Reactivity
Human
Clone
Application
ELISA, IHC, IF
Cat. No.
ABIN7166580
Quantity
100 μg
Reactivity
Human, Mouse, Rat
Clone
Application
WB, IHC
Cat. No.
ABIN3043894
Quantity
100 μg
Reactivity
Dog, Guinea Pig, Human, Mouse, Rabbit, Rat
Clone
Application
WB, IHC, IHC (p)
Cat. No.
ABIN202658
Quantity
100 μL
Reactivity
Human
Clone
C4
Application
WB, IHC, IP, ICC
Cat. No.
ABIN7426568
Quantity
100 μL
Markers for brown Adipocytes
Important markers of brown adipocytes include CIDEA, and PRDM16, Zic1, Lhx8, Eva1 and Epsti1.(4)(5)(6) PD-L1 is an activation-independent marker of brown adipocytes.(3) Click on the links to see all available products.
Product
Reactivity
Clone
Application
Validations
Cat. No.
Quantity
Reactivity
Human
Clone
Application
WB, FACS, ELISA, IF
Cat. No.
ABIN185339
Quantity
100 μg
Reactivity
Human
Clone
Application
WB, ELISA, IHC, IF
Cat. No.
ABIN7147273
Quantity
100 μg
Reactivity
Human
Clone
2A8
Application
ELISA, WB, IHC, IHC (p)
Cat. No.
ABIN574468
Quantity
50 μg
Reactivity
Human
Clone
Application
WB, IHC, IHC (p)
Cat. No.
ABIN604930
Quantity
50 μL
Reactivity
Human, Mouse
Clone
Application
ELISA, ChIP, FACS
Cat. No.
ABIN184809
Quantity
100 μg
Reactivity
Human
Clone
Application
WB, IF, IHC
Cat. No.
ABIN6740211
Quantity
100 μL
Other relevant Adipocyte Markers
Other relevant markers for adipocytes are listed below. Click on the links to see all available products.
Product
Reactivity
Clone
Application
Validations
Cat. No.
Quantity
Reactivity
Human
Clone
Application
WB, IHC, IF
Cat. No.
ABIN6145773
Quantity
100 μL
Reactivity
Human, Mouse
Clone
3G10A3
Application
WB, IHC, ELISA, ICC, FACS
Cat. No.
ABIN1724743
Quantity
100 μL
Reactivity
Human
Clone
Application
WB, IHC, IP, ICC
Cat. No.
ABIN7445093
Quantity
100 μL
Reactivity
Human
Clone
6B3A9
Application
ELISA, IHC
Cat. No.
ABIN1724864
Quantity
100 μL
Reactivity
Human
Clone
RB23213
Application
WB, FACS, IF
Cat. No.
ABIN651298
Quantity
400 μL
Reactivity
Human
Clone
Application
WB, IHC, ELISA, IF
Cat. No.
ABIN7143426
Quantity
100 μg
Reactivity
Human
Clone
Application
ELISA, IHC
Cat. No.
ABIN7238366
Quantity
200 μL
References
Rosen, Spiegelman: "
Adipocytes as regulators of energy balance and glucose homeostasis." in:
Nature,
Vol. 444,
Issue 7121,
pp. 847-53, (
2007) (
PubMed).
Garcia, Roemmich, Claycombe: "
Evaluation of markers of beige adipocytes in white adipose tissue of the mouse." in:
Nutrition & metabolism,
Vol. 13,
pp. 24, (
2016) (
PubMed).
Ingram, Dougan, Rashidian, Knoll, Keliher, Garrett, Garforth, Blomberg, Espinosa, Bhan, Almo, Weissleder, Lodish, Dougan, Ploegh: "
PD-L1 is an activation-independent marker of brown adipocytes." in:
Nature communications,
Vol. 8,
Issue 1,
pp. 647, (
2018) (
PubMed).
Waldén, Hansen, Timmons, Cannon, Nedergaard: "
Recruited vs. nonrecruited molecular signatures of brown, "brite," and white adipose tissues." in:
American journal of physiology. Endocrinology and metabolism,
Vol. 302,
Issue 1,
pp. E19-31, (
2012) (
PubMed).
Petrovic, Walden, Shabalina, Timmons, Cannon, Nedergaard: "
Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocyt" in:
The Journal of biological chemistry,
Vol. 285,
Issue 10,
pp. 7153-64, (
2010) (
PubMed).
Wu, Boström, Sparks, Ye, Choi, Giang, Khandekar, Virtanen, Nuutila, Schaart, Huang, Tu, van Marken Lichtenbelt, Hoeks, Enerbäck, Schrauwen, Spiegelman: "
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human." in:
Cell,
Vol. 150,
Issue 2,
pp. 366-76, (
2012) (
PubMed).
Rene von der Forst, MSE
Marketing and E-Commerce Manager
Master of Science in engineering. 12+ years of experience in marketing and e-commerce in the life science sector.
前往作者页面
