(ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 1 (ARAP1))
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
Hasegawa, Tsujita, Takenawa, Itoh: "ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5." in: Molecular biology of the cell, Vol. 23, Issue 13, pp. 2481-9, (2012) (PubMed).
Símová, Klíma, Cermak, Sourková, Andera: "Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane." in: Apoptosis : an international journal on programmed cell death, Vol. 13, Issue 3, pp. 423-36, (2008) (PubMed).
Komagiri, Kitamura: "Comparison of effects of PKA catalytic subunit on I(h) and calcium channel currents in rat dorsal root ganglion cells." in: Biomedical research (Tokyo, Japan), Vol. 28, Issue 4, pp. 177-89, (2007) (PubMed).
Miura, Jacques, Stauffer, Kubosaki, Zhu, Hirsch, Resau, Zheng, Randazzo: "ARAP1: a point of convergence for Arf and Rho signaling." in: Molecular cell, Vol. 9, Issue 1, pp. 109-19, (2002) (PubMed).
Ferraris, Persaud, Williams, Chen, Burg: "cAMP-independent role of PKA in tonicity-induced transactivation of tonicity-responsive enhancer/ osmotic response element-binding protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16800-5, (2002) (PubMed).