Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008].
Lindner, Beckenbauer, van Ek, Titeca, de Leeuw, Awwad, Hanke, Korepanova, Rybin, van der Kam, Mohler, Tackenberg, Lakics, Gavin: "Isoform- and cell-state-specific lipidation of ApoE in astrocytes." in: Cell reports, Vol. 38, Issue 9, pp. 110435, (2022) (PubMed).
Pan, Zhou, Mahsut, Rohm, Berejnaia, Price, Chen, Castro-Perez, Lassman, McLaren, Conway, Jensen, Thomas, Reyes-Soffer, Ginsberg, Gutstein, Cleary, Previs, Roddy: "Static and turnover kinetic measurement of protein biomarkers involved in triglyceride metabolism including apoB48 and apoA5 by LC/MS/MS." in: Journal of lipid research, Vol. 55, Issue 6, pp. 1179-87, (2016) (PubMed).
Krul, Cole: "Quantitation of apolipoprotein E." in: Methods in enzymology, Vol. 263, pp. 170-87, (1996) (PubMed).
Aliases for APOE 蛋白
apolipoprotein E (apoe) 蛋白 apolipoprotein Ea (apoea) 蛋白 apolipoprotein E (Apoe) 蛋白 apolipoprotein E (APOE) 蛋白 ad2 蛋白 AD2 蛋白 AI255918 蛋白 Apo-E 蛋白 apoe 蛋白 APOEA 蛋白 apoprotein 蛋白 im:7036787 蛋白 LDLCQ5 蛋白 LPG 蛋白 wu:fb69a05 蛋白 zgc:110064 蛋白