APOE 产品
(Apolipoprotein E (APOE))
Categories
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008].
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Featured APOE Categories
APOE 抗体
High quality antibodies with extensive validation data.
APOE ELISA试剂盒
Reliable ELISA kits for a wide range of species.
APOE 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended APOE 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (9)
Cat. No.
ABIN7429133
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (9)
Cat. No.
ABIN7429139
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Dog
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7440422
Quantity
100 μL
Datasheet
Datasheet
Recommended APOE ELISA试剂盒
Product
Reactivity
Analytical Method
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Cat. No.
Quantity
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Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
- (1)
Cat. No.
ABIN612665
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Competition ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6975758
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Competition ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6974557
Quantity
96 tests
Datasheet
Datasheet
Recommended APOE 蛋白
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Reactivity
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Validations
Cat. No.
Quantity
Datasheet
Reactivity
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Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7273868
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7273871
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
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Validations
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Cat. No.
ABIN7273869
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our APOE Products
: "Isoform- and cell-state-specific lipidation of ApoE in astrocytes." in: Cell reports, Vol. 38, Issue 9, pp. 110435, (2022) (PubMed).: "Hepatic HuR modulates lipid homeostasis in response to high-fat diet." in: Nature communications, Vol. 11, Issue 1, pp. 3067, (2020) (PubMed).
: "Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1β secretion by bronchoalveolar fluid macrophages from asthmatic subjects." in: The Journal of allergy and clinical immunology, Vol. 144, Issue 2, pp. 426-441.e3, (2020) (PubMed).
: "Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line." in: Stem cell research, Vol. 34, pp. 101349, (2019) (PubMed).
: "APOE ε2 is associated with increased tau pathology in primary tauopathy. ..." in: Nature communications, Vol. 9, Issue 1, pp. 4388, (2019) (PubMed).
: "Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7." in: EBioMedicine, Vol. 36, pp. 29-38, (2019) (PubMed).
: "Single-Cell RNA Sequencing Identifies Candidate Renal Resident Macrophage Gene Expression Signatures across Species." in: Journal of the American Society of Nephrology : JASN, Vol. 30, Issue 5, pp. 767-781, (2019) (PubMed).
: "Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 38, Issue 8, pp. e145-e158, (2019) (PubMed).
: "Evaluation of α-synuclein and apolipoprotein E as potential biomarkers in cerebrospinal fluid to monitor pharmacotherapeutic efficacy in dopamine dictated disease states of Parkinson's disease and ..." in: Neuropsychiatric disease and treatment, Vol. 15, pp. 2073-2085, (2019) (PubMed).
: "Hypolipidemic and anti-inflammatory effects of aorta and heart tissues of cattle and pigs in the atherosclerosis rat model." in: Animal science journal = Nihon chikusan Gakkaihō, Vol. 89, Issue 5, pp. 784-793, (2018) (PubMed).
Synonyms and alternative names related to APOE
apolipoprotein E (apoe), apolipoprotein Ea (apoea), apolipoprotein E (Apoe), apolipoprotein E (APOE), ad2, AD2, AI255918, Apo-E, apoe, APOEA, apoprotein, im:7036787, LDLCQ5, LPG, wu:fb69a05, zgc:110064Protein level used designations for APOE
- apolipoprotein E
- ApoE-1
- apo-E
- apolipoprotein E3
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