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APH1A 抗体

(Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))
This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011].

59 results

APH1A 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal FITC
产品编号 ABIN1893449
 
APH1A 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal PE
产品编号 ABIN1893450
 
APH1A 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal FITC
产品编号 ABIN1893442
 
APH1A 适用: 小鼠 WB 宿主: 兔 Polyclonal RB39321 unconjugated
产品编号 ABIN1539365
 
APH1A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5027035
 
APH1A 适用: 人, 小鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN499307
 
APH1A 适用: 人, 小鼠, 大鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7602846
 
APH1A 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2201500
 
APH1A 适用: 人 ELISA, IF/ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6081776
 
APH1A 适用: 人 ELISA 宿主: 兔 Polyclonal HRP
产品编号 ABIN6081778
 
APH1A 适用: 人 ELISA 宿主: 兔 Polyclonal FITC
产品编号 ABIN6081780
 
APH1A 适用: 人 ELISA 宿主: 兔 Polyclonal Biotin
产品编号 ABIN6081782
 
APH1A 适用: 人, 小鼠 宿主: 兔 Polyclonal Alexa Fluor 680
产品编号 ABIN6899526
 
APH1A 适用: 人, 小鼠 宿主: 兔 Polyclonal Alexa Fluor 555
产品编号 ABIN6883463
 
APH1A 适用: 人, 小鼠 宿主: 兔 Polyclonal Alexa Fluor 488
产品编号 ABIN6811084
 
APH1A 适用: 人, 小鼠 宿主: 兔 Polyclonal Alexa Fluor 750
产品编号 ABIN6851337
 
APH1A 适用: 人, 小鼠 宿主: 兔 Polyclonal Alexa Fluor 594
产品编号 ABIN6827147
 
APH1A 适用: 人, 小鼠 宿主: 兔 Polyclonal Alexa Fluor 647
产品编号 ABIN6843210
 
APH1A 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2202306
 
  • 类型 Primary
    • Primary
  • 应用范围
    • Western Blotting (WB)
    • ELISA
    • Flow Cytometry (FACS)
    • Immunofluorescence (Cultured Cells) (IF (cc))
    • Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    • Immunohistochemistry (IHC)
    • Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    • Immunofluorescence (IF)
    • Immunohistochemistry (Frozen Sections) (IHC (fro))
    • Enzyme Immunoassay (EIA)
    • Immunocytochemistry (ICC)
    • Immunofluorescence (fixed cells) (IF/ICC)
  • 适用
    • Human
    • Mouse
    • Rat
    • Cow
    • Dog
    • Horse
    • Monkey
    • Opossum
  • 图像
  • Preservative free only
  • Carrier free only
  • 抗体来源
    • Rabbit
    • Goat
  • 克隆形成能力
    • Polyclonal
  • 克隆
    • RB39321
    • RB4994
  • 抗原表位
    • AA 71-170
    • AA 41-70
    • AA 77-109
    • N-Term
    • AA 1-247
    • AA 90-118
    • C-Term
    • AA 80-130
    • AA 11-245
    • AA 207-265
    • AA 246-265
    • AA 40-90
    • Internal Region
    • Middle Region
  • 标记
    • 非结合性
    • Biotin
    • FITC
    • HRP
    • PE
    • APC
    • AbBy Fluor® 350
    • AbBy Fluor® 488
    • AbBy Fluor® 555
    • AbBy Fluor® 594
    • AbBy Fluor® 647
    • AbBy Fluor® 680
    • AbBy Fluor® 750
    • Alexa Fluor 488
    • Alexa Fluor 555
    • Alexa Fluor 594
    • Alexa Fluor 647
    • Alexa Fluor 680
    • Alexa Fluor 750
    • Cy3
    • Cy5
    • Cy5.5
    • Cy7
  • 抗体亚型
    • IgG
    • Ig Fraction
  • Format
    • Liquid
    • Lyophilized
  • Grade
    • Verified
  • Supplier
    • antibodies-online
    • Signalway
    • Abbexa
    • Abcepta
    • Acris
    • USBio
    • Abeomics
    • Boster Bio

Latest Publications for our APH1A 抗体

Area-Gomez, de Groof, Boldogh, Bird, Gibson, Koehler, Yu, Duff, Yaffe, Pon, Schon: "Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria." in: The American journal of pathology, Vol. 175, Issue 5, pp. 1810-6, (2009) (PubMed).

Spasic, Raemaekers, Dillen, Declerck, Baert, Serneels, Füllekrug, Annaert: "Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway." in: The Journal of cell biology, Vol. 176, Issue 5, pp. 629-40, (2007) (PubMed).

Ma, Li, Price, Wong: "APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 25, Issue 1, pp. 192-8, (2005) (PubMed).

Periz, Fortini: "Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2." in: Journal of neuroscience research, Vol. 77, Issue 3, pp. 309-22, (2004) (PubMed).

Takasugi, Tomita, Hayashi, Tsuruoka, Niimura, Takahashi, Thinakaran, Iwatsubo: "The role of presenilin cofactors in the gamma-secretase complex." in: Nature, Vol. 422, Issue 6930, pp. 438-41, (2003) (PubMed).

Marlow, Canet, Haugabook, Hardy, Lahiri, Sambamurti: "APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity." in: Biochemical and biophysical research communications, Vol. 305, Issue 3, pp. 502-9, (2003) (PubMed).

Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, (2003) (PubMed).

Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, (2003) (PubMed).

Gu, Chen, Sanjo, Kawarai, Hasegawa, Duthie, Li, Ruan, Luthra, Mount, Tandon, Fraser, St George-Hyslop: "APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes." in: The Journal of biological chemistry, Vol. 278, Issue 9, pp. 7374-80, (2003) (PubMed).

Goutte, Tsunozaki, Hale, Priess: "APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 2, pp. 775-9, (2002) (PubMed).

Aliases for APH1A 抗体

aph-1 homolog A, gamma-secretase subunit (APH1A) 抗体
aph-1 homolog A, gamma secretase subunit L homeolog (aph1a.L) 抗体
aph-1 homolog A, gamma secretase subunit (Aph1a) 抗体
anterior pharynx defective 1 homolog A (C. elegans) (APH1A) 抗体
aph1 homolog A, gamma secretase subunit (Aph1a) 抗体
acylamino-acid-releasing enzyme-like (LOC100219182) 抗体
6530402N02Rik 抗体
APH-1 抗体
APH-1A 抗体
APH-1a 抗体
CGI-78 抗体
RGD1311546 抗体
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