APC 抗体
(Adenomatous Polyposis Coli (APC))
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008].
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127 results
APC
适用: 人
WB, ELISA, IF, FACS, Coat
宿主: 小鼠
Monoclonal
ALi 12-28
unconjugated
1 image
Latest Publications for our APC 抗体
: "Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum." in: Nature communications, Vol. 9, Issue 1, pp. 2830, (2018) (PubMed).: "Promoter methylation status of tumor suppressor genes and inhibition of expression of DNA methyltransferase 1 in non-small cell lung cancer." in: Experimental biology and medicine (Maywood, N.J.), Vol. 241, Issue 14, pp. 1531-9, (2017) (PubMed).
: "Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesis." in: Oncogene, (2016) (PubMed).
: "Genetic reconstitution of tumorigenesis in primary intestinal cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 27, pp. 11127-32, (2013) (PubMed).
: "Plasma membrane recruitment of dephosphorylated beta-catenin upon activation of the Wnt pathway." in: Journal of cell science, Vol. 121, Issue Pt 11, pp. 1793-802, (2008) (PubMed).
: "Cadherins, catenins and APC in pleural malignant mesothelioma." in: The Journal of pathology, Vol. 201, Issue 3, pp. 355-62, (2003) (PubMed).
Aliases for APC 抗体
APC, WNT signaling pathway regulator (APC) 抗体adenomatous polyposis coli (apc) 抗体
adenomatous polyposis coli protein, putative (Smp_139190) 抗体
adenomatosis polyposis coli (Apc) 抗体
APC, WNT signaling pathway regulator (Apc) 抗体
adenomatous polyposis coli L homeolog (apc.L) 抗体
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