(Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 2 (APBB2))
The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
Hong, Hsu, Schultz, Pratt, Mattison, Chang: "Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response." in: BMC molecular biology, Vol. 8, pp. 50, (2007) (PubMed).
Aliases for APBB2 抗体
amyloid beta precursor protein binding family B member 2 (APBB2) 抗体 amyloid beta (A4) precursor protein-binding, family B, member 2 (Apbb2) 抗体 amyloid beta precursor protein binding family B member 2 (Apbb2) 抗体 amyloid beta precursor protein binding family B member 2 (apbb2) 抗体 amyloid beta (A4) precursor protein-binding, family B, member 2b (apbb2b) 抗体 2310007D03Rik 抗体 APBB2 抗体 DKFZp469I236 抗体 FE65L 抗体 fe65l 抗体 FE65L1 抗体 fe65l1 抗体 RGD1562438 抗体 Rirl1 抗体 si:ch211-201g8.2 抗体 TR2L 抗体 Zfra 抗体