RAP1A 抗体
Quick Overview for RAP1A 抗体 (ABIN969561)
抗原
See all RAP1A 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- RAP1A Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human RAP1A expressed in E. Coli.
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亚型
- IgG1
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration." in: Molecular biology of the cell, Vol. 20, Issue 7, pp. 1916-25, (2009) (PubMed).
: "Dynamic changes in Rap1 activity are required for cell retraction and spreading during mitosis." in: Journal of cell science, Vol. 122, Issue Pt 16, pp. 2996-3004, (2009) (PubMed).
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: "Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration." in: Molecular biology of the cell, Vol. 20, Issue 7, pp. 1916-25, (2009) (PubMed).
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- RAP1A (RAP1A, Member of RAS Oncogene Family (RAP1A))
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别名
- RAP1A
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背景
- The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50 % amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.
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分子量
- 21 kDa
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UniProt
- P62834
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途径
- TCR Signaling, Neurotrophin Signaling Pathway, Signaling of Hepatocyte Growth Factor Receptor
抗原
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