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RAP1A 抗体

This anti-RAP1A antibody is a 小鼠 单克隆 antibody detecting RAP1A in ELISA 和 FACS. Suitable for 人. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN969561
发货至: 中国

Quick Overview for RAP1A 抗体 (ABIN969561)

抗原

See all RAP1A 抗体
RAP1A (RAP1A, Member of RAS Oncogene Family (RAP1A))

适用

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宿主

  • 52
  • 4
小鼠

克隆类型

  • 53
  • 3
单克隆

标记

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This RAP1A antibody is un-conjugated

应用范围

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ELISA, Flow Cytometry (FACS)

克隆位点

5F8
  • 原理

    RAP1A Antibody

    纯化方法

    Purified antibody

    免疫原

    Purified recombinant fragment of human RAP1A expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified antibody in PBS with 0.05 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Severson, Lee, Capaldo, Nusrat, Parkos: "Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration." in: Molecular biology of the cell, Vol. 20, Issue 7, pp. 1916-25, (2009) (PubMed).

    Dao, Dupuy, Gavet, Caron, de Gunzburg: "Dynamic changes in Rap1 activity are required for cell retraction and spreading during mitosis." in: Journal of cell science, Vol. 122, Issue Pt 16, pp. 2996-3004, (2009) (PubMed).

  • 抗原

    RAP1A (RAP1A, Member of RAS Oncogene Family (RAP1A))

    别名

    RAP1A

    背景

    The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50 % amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.

    分子量

    21 kDa

    UniProt

    P62834

    途径

    TCR Signaling, Neurotrophin Signaling Pathway, Signaling of Hepatocyte Growth Factor Receptor
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