MUSK 抗体 (AA 24-209)
(1 reference)Quick Overview for MUSK 抗体 (AA 24-209) (ABIN969299)
抗原
See all MUSK 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 24-209
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原理
- MUSK Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant extracellular fragment of human MUSK (aa24-209) fused with hIgGFc tag expressed in HEK293 cell line.
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亚型
- IgG1
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anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 517-777) antibody
MUSK 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 35-65), (N-Term) antibodyMUSK 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB01497 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 35-65) antibodyMUSK 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 301-400) antibodyMUSK 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2H6 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) antibodyMUSK 适用: 人, 小鼠 WB, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 829-859) antibodyMUSK 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) antibodyMUSK 适用: 人, 小鼠 WB, FACS, IF 宿主: 兔 Polyclonal RB14743 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 301-400) antibodyMUSK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F3 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) antibodyMUSK 适用: 小鼠, 大鼠 WB, IHC (p) 宿主: 小鼠 Monoclonal 6D1 unconjugated
anti-Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) (AA 600-860) antibodyMUSK 适用: 小鼠, 大鼠 WB, IHC (p) 宿主: 小鼠 Monoclonal 1429CT456-173-44 unconjugated
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应用备注
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ELISA: 1/10000
ICC: 1/200 - 1/1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Major pathogenic effects of anti-MuSK antibodies in myasthenia gravis." in: Journal of neuroimmunology, Vol. 177, Issue 1-2, pp. 119-31, (2006) (PubMed).
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: "Major pathogenic effects of anti-MuSK antibodies in myasthenia gravis." in: Journal of neuroimmunology, Vol. 177, Issue 1-2, pp. 119-31, (2006) (PubMed).
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- MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))
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别名
- MUSK
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背景
- MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.
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分子量
- 97 kDa
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基因ID
- 4593
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UniProt
- O15146
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途径
- RTK signaling, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development
抗原
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