ITGA5 抗体
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北京 101111
Quick Overview for ITGA5 抗体 (ABIN969221)
抗原
See all ITGA5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- ITGA5 Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of human ITGA5 expressed in E. Coli.
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亚型
- IgG2a
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anti-Integrin, alpha 5 (ITGA5) antibody
ITGA5 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated
anti-Integrin, alpha 5 (ITGA5) (AA 42-263) antibodyITGA5 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha 5 (ITGA5) (AA 1021-1099) antibodyITGA5 适用: 人, 小鼠 WB, ELISA, IHC (fro), IHC (p), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha 5 (ITGA5) antibodyKD Validated ITGA5 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB1050 unconjugated Recombinant Antibody
anti-Integrin, alpha 5 (ITGA5) antibodyKD Validated ITGA5 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 23GB880 unconjugated Recombinant Antibody
anti-Integrin, alpha 5 (ITGA5) (AA 111-253) antibodyITGA5 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 6F6C1 unconjugated
anti-Integrin, alpha 5 (ITGA5) (AA 111-253) antibodyITGA5 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 8D1G12 unconjugated
anti-Integrin, alpha 5 (ITGA5) (AA 750-1000) antibodyITGA5 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha 5 (ITGA5) (AA 220-472) antibodyITGA5 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha 5 (ITGA5) (Internal Region) antibodyITGA5 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain." in: The Journal of biological chemistry, Vol. 277, Issue 22, pp. 19800-5, (2002) (PubMed).
: "Integrin activation by regulated dimerization and oligomerization of platelet endothelial cell adhesion molecule (PECAM)-1 from within the cell." in: The Journal of cell biology, Vol. 152, Issue 1, pp. 65-73, (2001) (PubMed).
: "PECAM-1/CD31 trans-homophilic binding at the intercellular junctions is independent of its cytoplasmic domain; evidence for heterophilic interaction with integrin alphavbeta3 in Cis." in: Molecular biology of the cell, Vol. 11, Issue 9, pp. 3109-21, (2000) (PubMed).
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: "Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain." in: The Journal of biological chemistry, Vol. 277, Issue 22, pp. 19800-5, (2002) (PubMed).
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- ITGA5 (Integrin, alpha 5 (ITGA5))
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别名
- ITGA5
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背景
- The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 is a heterodimer that associates noncovalently with CD29/integrin beta 1 subunit to form the alpha-5-beta-1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc-gamma-R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues.
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分子量
- 114 kDa
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基因ID
- 3678
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UniProt
- P08648
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途径
- Integrin Complex
抗原
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