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ERBB3 抗体 (AA 22-369)

ERBB3 适用: 人 WB, ELISA, ICC 宿主: 小鼠 Monoclonal 2F9 unconjugated
产品编号 ABIN969114
发货至: 中国
  • 抗原 See all ERBB3 抗体
    ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
    抗原表位
    • 29
    • 26
    • 21
    • 15
    • 15
    • 14
    • 12
    • 12
    • 8
    • 7
    • 3
    • 3
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    • 2
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    • 2
    • 2
    • 1
    • 1
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    • 1
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    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    AA 22-369
    适用
    • 188
    • 130
    • 113
    • 17
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    宿主
    • 194
    • 30
    • 1
    • 1
    小鼠
    克隆类型
    • 191
    • 35
    单克隆
    标记
    • 116
    • 14
    • 10
    • 10
    • 10
    • 10
    • 10
    • 10
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    This ERBB3 antibody is un-conjugated
    应用范围
    • 109
    • 71
    • 55
    • 53
    • 53
    • 32
    • 30
    • 25
    • 22
    • 16
    • 7
    • 3
    • 3
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    • 2
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC)
    纯化方法
    purified
    免疫原
    Purified recombinant extracellular fragment of human ERBB3 (aa22-369) fused with hIgGFc tag expressed in HEK293 cells.
    克隆位点
    2F9
    亚型
    IgG1
    Top Product
    Discover our top product ERBB3 Primary Antibody
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • Sassen, Rochon, Wild, Hartmann, Hofstaedter, Schwarz, Brockhoff: "Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients." in: Breast cancer research : BCR, Vol. 10, Issue 1, pp. R2, (2008) (PubMed).

    Sakai, Yokote, Murakami-Murofushi, Tamura, Saijo, Nishio: "Pertuzumab, a novel HER dimerization inhibitor, inhibits the growth of human lung cancer cells mediated by the HER3 signaling pathway." in: Cancer science, Vol. 98, Issue 9, pp. 1498-503, (2007) (PubMed).

  • 抗原
    ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
    别名
    ERBB3 (ERBB3 产品)
    别名
    ErbB-3 antibody, HER3 antibody, LCCS2 antibody, MDA-BF-1 antibody, c-erbB-3 antibody, c-erbB3 antibody, erbB3-S antibody, p180-ErbB3 antibody, p45-sErbB3 antibody, p85-sErbB3 antibody, ERBB3 antibody, C76256 antibody, Erbb-3 antibody, Erbb3r antibody, Her3 antibody, nuc-ErbB3 antibody, erb-b2 receptor tyrosine kinase 3 antibody, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody, ERBB3 antibody, Erbb3 antibody
    背景

    Description: ERBB3, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian). It is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

    Aliases: HER3, c-erbB3

    分子量
    148 kDa
    基因ID
    2065
    HGNC
    2065
    途径
    RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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