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ErbB2/Her2 抗体 (AA 750-987)

This anti-ErbB2/Her2 antibody is a Mouse Monoclonal antibody detecting ErbB2/Her2 in WB, IHC, ELISA, FACS. Suitable for Human. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN969111
发货至: 中国

Quick Overview for ErbB2/Her2 抗体 (AA 750-987) (ABIN969111)

抗原

See all ErbB2/Her2 抗体
ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

适用

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小鼠

克隆类型

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单克隆

标记

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This ErbB2/Her2 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

克隆位点

6C2
  • 抗原表位

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    AA 750-987

    原理

    ERBB2 Antibody

    纯化方法

    Ascitic fluid

    免疫原

    Purified recombinant fragment of human ERBB2(aa750-987) expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Ascitic fluid containing 0.03 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Yamauchi, Stearns, Hayes: "When is a tumor marker ready for prime time? A case study of c-erbB-2 as a predictive factor in breast cancer." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 19, Issue 8, pp. 2334-56, (2001) (PubMed).

  • 抗原

    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

    别名

    ERBB2

    背景

    ERBB2: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian). This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

    分子量

    180 kDa

    UniProt

    P04626

    途径

    RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
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