EZH2 抗体 (AA 156-256)
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北京 101111
Quick Overview for EZH2 抗体 (AA 156-256) (ABIN968907)
抗原
See all EZH2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 156-256
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交叉反应
- 犬, 大鼠, 小鼠, 小鸡
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human EZH2 recombinant protein aa. 156-256
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亚型
- IgG1
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anti-Enhancer of Zeste Homolog 2 (EZH2) antibody
EZH2 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 144CT2-1-1-5 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-296), (N-Term) antibodyEZH2 适用: 人, 小鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB23144 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 51-285) antibodyEZH2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-194) antibodyEZH2 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 6G4F4 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 410-440) antibodyEZH2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2921 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) antibodyEZH2 适用: 人, 小鼠 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-154) antibodyEZH2 适用: 人, 小鼠 WB, IHC, ICC, FACS, IP 宿主: 兔 Monoclonal BLR338M unconjugated Recombinant Antibody
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 696-746) antibodyEZH2 适用: 人, 小鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) antibodyKD Validated EZH2 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 24GB7200 unconjugated
anti-Enhancer of Zeste Homolog 2 (EZH2) antibodyEZH2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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说明
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Related Products: ABIN968537, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20°C.
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: "Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 10, pp. 5925-34, (2001) (PubMed).
: "Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma." in: Blood, Vol. 97, Issue 12, pp. 3896-901, (2001) (PubMed).
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- EZH2 (Enhancer of Zeste Homolog 2 (EZH2))
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别名
- EZH2
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背景
- The 11/EZH2 monoclonal antibody specifically binds to the methyltransferase, EZH2 (Enhancer of Zeste Homolog 2). EZH2 is a human homologue of Drosophila's Enhancer of zeste gene, an important regulator of homeobox gene expression. The EZH2 protein has a predicted molecular weight of ~85 kDa. EZH2 is a member of the Polycomb group (PcG) of proteins that are essential for the maintenance, but not initiation, of the transcriptionally repressed state of certain developmental genes. PcG proteins are a structurally diverse group of proteins with conserved functions from fly to human cells. PcG family proteins form multimeric complexes that regulate the expression of genes involved in cell cycle, DNA repair and differentiation. Specifically, EZH2 is a core enzymatic component of PRC2 (polycomb repressive complex 2). EZH2 is expressed in some lymph node follicular T cells and B cells. Thymocytes differentially express EZH2 at various stages during T-cell maturation. EZH2 interacts with multiple signaling proteins, including Vav, that are involved in lymphocyte development and activation. It is highly expressed in a variety of tumors including lymphomas as well as breast and prostate cancers. EZH2 is important in the self renewal and proliferation of numerous stem cell types including fetal hematopoietic stem cells, muscle satellite cells, hepatic stem/progenitor cells, neural stem cells, basal cell progenitors in the developing epidermis, embryonic stem cells, and some cancer stem cells.
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分子量
- 91 kDa
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途径
- Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation
抗原
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