FKBP1A 抗体 (AA 1-108)
(2 references)Quick Overview for FKBP1A 抗体 (AA 1-108) (ABIN968189)
抗原
See all FKBP1A 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-108
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交叉反应
- 小鼠, 犬, 小鸡
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human FKBP12 aa. 1-108
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亚型
- IgG1
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anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 55-83), (C-Term) antibody
FKBP1A 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB19307 unconjugated
anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 1-108) antibodyFKBP1A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E5-A12 unconjugated
anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 1-108) antibodyFKBP1A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 2-103) antibodyFKBP1A 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) antibodyFKBP1A 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 2-108) antibodyFKBP1A 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 2-108) antibodyFKBP1A 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal E3 unconjugated
anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) (N-Term) antibodyFKBP1A 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) antibodyFKBP1A 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 43-74) antibodyFKBP1A 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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说明
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Related Products: ABIN968552, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20° C.
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: "Mechanism of TGFbeta receptor inhibition by FKBP12." in: The EMBO journal, Vol. 16, Issue 13, pp. 3866-76, (1997) (PubMed).
: "Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12." in: Science (New York, N.Y.), Vol. 265, Issue 5172, pp. 674-6, (1994) (PubMed).
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: "Mechanism of TGFbeta receptor inhibition by FKBP12." in: The EMBO journal, Vol. 16, Issue 13, pp. 3866-76, (1997) (PubMed).
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- FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))
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别名
- FKBP12
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背景
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Transforming growth factor-beta binds to the TGFbeta family of heteromeric serine/threonine transmembrane receptors (type I and type II). Following binding of TGFbeta, the type II receptor (TbetaR-II) phosphorylates the type I receptor (TbetaR-I) which, in turn, conveys the signal. Since TbetaR-I and TbetaR-II can interact without the stimulation of TGFbeta, leading to unwanted activation, a regulatory mechanism exists. In a yeast genetic screen, immunophilin FKBP12 was associated with the type I receptor. Studies including co-immunoprecipiation, deletion, and point mutations confirmed this interaction. FKBP12 inhibits TbetaR-II mediated phosphorylation of TbetaR-I, inhibiting activation. FKBP12 binds via its rapamycin/Leu-Pro binding pocket to the Leu-Pro sequence adjacent to the phosphorylation site of TbetaR-I. This interaction is blocked by the addition of macrolides, rapamycin, and FK506. Furthermore, mutations in the binding sites of FKBP12 and TbetaR-I abrogates the binding and results in activation of the receptor without the addition of TGFbeta. Thus, FKBP12 is a regulatory protein for TbetaR-I and TbetaR-II-mediated signaling.
Synonyms: FK506 Binding Protein 1A -
分子量
- 14 kDa
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途径
- Negative Regulation of Transporter Activity, Methionine Biosynthetic Process
抗原
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