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FKBP1A 抗体 (AA 1-108)

Name: FKBP1A 抗体 (AA 1-108)
SKU: ABIN968189
Availability: OutOfStock

This anti-FKBP1A antibody is a 小鼠单克隆 antibody detecting FKBP1A in WB, IHC, IP 和 IF. Suitable for 人, 小鼠, 犬和小鸡. This Primary Antibody has been cited in 2+ publications.

Western blot analysis of FKBP12 on a SW-13 cell lysate (Human adrenal gland carcinoma, ATCC CCL-105). (FKBP1A 抗体 (AA 1-108))

Image no. 1 for anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 1-108) antibody (ABIN968189) (FKBP1A 抗体 (AA 1-108))

Immunofluorescence staining of HS 766T cells (Human pancreatic carcinoma, ATCC HTB-134). (FKBP1A 抗体 (AA 1-108))

3 images

(2 references)

产品编号 ABIN968189

发货至: 中国

Quick Overview for FKBP1A 抗体 (AA 1-108) (ABIN968189)

抗原

See all FKBP1A 抗体

FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

适用

人, 小鼠, 犬, 小鸡

宿主

小鼠

克隆类型

单克隆

标记

This FKBP1A antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

克隆位点

8-FKBP12

Discover our top product FKBP1A Primary Antibody

抗原表位
12

11

6

4

3

2

2

1

1

1

1
AA 1-108

交叉反应

小鼠, 犬, 小鸡

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human FKBP12 aa. 1-108

亚型

IgG1
anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 55-83), (C-Term) antibody
FKBP1A 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB19307 unconjugated

anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 1-108) antibody
FKBP1A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E5-A12 unconjugated

anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 1-108) antibody
FKBP1A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 2-103) antibody
FKBP1A 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) antibody
FKBP1A 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated

anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 2-108) antibody
FKBP1A 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 2-108) antibody
FKBP1A 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal E3 unconjugated

anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) (N-Term) antibody
FKBP1A 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) antibody
FKBP1A 适用: 人 WB 宿主: 兔 Monoclonal unconjugated

anti-FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 43-74) antibody
FKBP1A 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

说明

Related Products: ABIN968552, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20° C.
Chen, Liu, Massague: "Mechanism of TGFbeta receptor inhibition by FKBP12." in: The EMBO journal, Vol. 16, Issue 13, pp. 3866-76, (1997) (PubMed).

Wang, Donahoe, Zervos: "Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12." in: Science (New York, N.Y.), Vol. 265, Issue 5172, pp. 674-6, (1994) (PubMed).
抗原

FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

别名

FKBP12

背景

Transforming growth factor-beta binds to the TGFbeta family of heteromeric serine/threonine transmembrane receptors (type I and type II). Following binding of TGFbeta, the type II receptor (TbetaR-II) phosphorylates the type I receptor (TbetaR-I) which, in turn, conveys the signal. Since TbetaR-I and TbetaR-II can interact without the stimulation of TGFbeta, leading to unwanted activation, a regulatory mechanism exists. In a yeast genetic screen, immunophilin FKBP12 was associated with the type I receptor. Studies including co-immunoprecipiation, deletion, and point mutations confirmed this interaction. FKBP12 inhibits TbetaR-II mediated phosphorylation of TbetaR-I, inhibiting activation. FKBP12 binds via its rapamycin/Leu-Pro binding pocket to the Leu-Pro sequence adjacent to the phosphorylation site of TbetaR-I. This interaction is blocked by the addition of macrolides, rapamycin, and FK506. Furthermore, mutations in the binding sites of FKBP12 and TbetaR-I abrogates the binding and results in activation of the receptor without the addition of TGFbeta. Thus, FKBP12 is a regulatory protein for TbetaR-I and TbetaR-II-mediated signaling.
Synonyms: FK506 Binding Protein 1A

分子量

14 kDa

途径

Negative Regulation of Transporter Activity, Methionine Biosynthetic Process