ALOX5 抗体 (AA 442-590)
(5 references)-
- 抗原 See all ALOX5 抗体
- ALOX5 (Arachidonate 5-Lipoxygenase (ALOX5))
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抗原表位
- AA 442-590
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适用
- 人, 大鼠, 小鼠, 小鸡
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This ALOX5 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
- 交叉反应
- 小鸡, 大鼠, 小鼠
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human 5-Lipoxygenase aa. 442-590
- 克隆位点
- 33-5
- 亚型
- IgG1
- Top Product
- Discover our top product ALOX5 Primary Antibody
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anti-Arachidonate 5-Lipoxygenase (ALOX5) (AA 461-671) antibody
ALOX5 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Arachidonate 5-Lipoxygenase (ALOX5) (AA 1-674) antibodyALOX5 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Arachidonate 5-Lipoxygenase (ALOX5) (AA 1-300) antibodyALOX5 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Arachidonate 5-Lipoxygenase (ALOX5) antibodyALOX5 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Arachidonate 5-Lipoxygenase (ALOX5) (AA 120-483) antibodyALOX5 适用: 人, 大鼠, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Arachidonate 5-Lipoxygenase (ALOX5) (AA 601-674) antibodyALOX5 适用: 人, 大鼠, 小鼠 IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Arachidonate 5-Lipoxygenase (ALOX5) (C-Term) antibodyALOX5 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Arachidonate 5-Lipoxygenase (ALOX5) (AA 461-671) antibodyALOX5 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal D10 unconjugated
anti-Arachidonate 5-Lipoxygenase (ALOX5) (AA 2-149) antibodyALOX5 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Arachidonate 5-Lipoxygenase (ALOX5) antibodyALOX5 适用: 人, 大鼠, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN967389, ABIN968554
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
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: "Elevated levels of cyclooxygenase-2 in antigen-stimulated mast cells is associated with minimal activation of p38 mitogen-activated protein kinase." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 3, pp. 1629-36, (2001) (PubMed).
: "New induction of leukotriene A(4) hydrolase by interleukin-4 and interleukin-13 in human polymorphonuclear leukocytes." in: Blood, Vol. 96, Issue 2, pp. 601-9, (2000) (PubMed).
: "Tyrosine kinase activity modulates catalysis and translocation of cellular 5-lipoxygenase." in: The Journal of biological chemistry, Vol. 271, Issue 11, pp. 6179-84, (1996) (PubMed).
: "5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins." in: The Journal of biological chemistry, Vol. 269, Issue 39, pp. 24163-8, (1994) (PubMed).
: "Molecular cloning and amino acid sequence of human 5-lipoxygenase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 1, pp. 26-30, (1988) (PubMed).
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: "Elevated levels of cyclooxygenase-2 in antigen-stimulated mast cells is associated with minimal activation of p38 mitogen-activated protein kinase." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 3, pp. 1629-36, (2001) (PubMed).
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- 抗原
- ALOX5 (Arachidonate 5-Lipoxygenase (ALOX5))
- 别名
- 5-Lipoxygenase (ALOX5 产品)
- 别名
- 5-LO antibody, 5-LOX antibody, 5LPG antibody, LOG5 antibody, 5LO antibody, 5LX antibody, AI850497 antibody, F730011J02 antibody, LOX5A antibody, si:dkey-194n13.2 antibody, lox5 antibody, arachidonate 5-lipoxygenase antibody, arachidonate 5-lipoxygenase a antibody, Arachidonate 5-lipoxygenase antibody, ALOX5 antibody, Alox5 antibody, alox5a antibody, AFUA_4G02770 antibody, AOR_1_1362014 antibody, lox5 antibody
- 背景
- 5-Lipoxygenase (5-LO) is the initial enzyme that converts arachidonic acid to leukotrienes, which are important inflammatory and vasoconstrictive metabolites. It is activated in response to a number of stimuli, such as differentiation and allergen challenges. The 5-LO gene, abundantly expressed in placenta, lung, and leukocytes, encodes a protein of 674 amino acids with an apparent molecular weight of 78kDa. 5-LO is a Ca2+ and ATP-dependent enzyme that translocates from the cytosol to either a nuclear or plasma membrane compartment following activation. A proline-rich domain of 5-LO (amino acids 566-577) has been identified as a binding site for the PTyr-binding protein, Grb2. This Grb2 site links tyrosine kinases with activation and redistribution of 5-LO. Furthermore, tyrosine kinase inhibitors increase the activity of 5-LO and block the enzyme's subcellular redistribution.
- 分子量
- 79 kDa
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