ITGA5 抗体 (AA 853-1002)
(5 references)Quick Overview for ITGA5 抗体 (AA 853-1002) (ABIN968077)
抗原
See all ITGA5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 853-1002
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Please refer to us for technical protocols. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human Integrin alpha5 aa. 853-1002
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亚型
- IgG2a
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anti-Integrin, alpha 5 (ITGA5) (AA 42-263) antibody
ITGA5 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha 5 (ITGA5) (AA 1021-1099) antibodyITGA5 适用: 人, 小鼠 WB, ELISA, IHC (fro), IHC (p), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha 5 (ITGA5) antibodyITGA5 适用: 人 FACS, ELISA, IHC 宿主: 小鼠 Monoclonal 10F6 unconjugated
anti-Integrin, alpha 5 (ITGA5) (AA 111-253) antibodyITGA5 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 6F6C1 unconjugated
anti-Integrin, alpha 5 (ITGA5) (AA 111-253) antibodyITGA5 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 8D1G12 unconjugated
anti-Integrin, alpha 5 (ITGA5) (AA 220-472) antibodyITGA5 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha 5 (ITGA5) (Internal Region) antibodyITGA5 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha 5 (ITGA5) (AA 750-1000) antibodyITGA5 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin, alpha 5 (ITGA5) (AA 575-602) antibodyITGA5 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB20677 unconjugated
anti-Integrin, alpha 5 (ITGA5) (AA 649-900) antibodyITGA5 适用: Cow WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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说明
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Related Products: ABIN968535, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20° C.
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: "Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions." in: Molecular biology of the cell, Vol. 13, Issue 10, pp. 3546-59, (2002) (PubMed).
: "Nischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migration." in: The Journal of cell biology, Vol. 151, Issue 6, pp. 1141-54, (2001) (PubMed).
: "Anchorage-dependent regulation of the mitogen-activated protein kinase cascade by growth factors is supported by a variety of integrin alpha chains." in: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31223-8, (1999) (PubMed).
: "Functional role of N-glycosylation in alpha 5 beta 1 integrin receptor. De-N-glycosylation induces dissociation or altered association of alpha 5 and beta 1 subunits and concomitant loss of ..." in: The Journal of biological chemistry, Vol. 269, Issue 16, pp. 12325-31, (1994) (PubMed).
: "Functional role of the cytoplasmic domain of the integrin alpha 5 subunit." in: The Journal of cell biology, Vol. 122, Issue 1, pp. 209-21, (1993) (PubMed).
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: "Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions." in: Molecular biology of the cell, Vol. 13, Issue 10, pp. 3546-59, (2002) (PubMed).
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- ITGA5 (Integrin, alpha 5 (ITGA5))
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别名
- CD49e
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背景
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Integrins are membrane receptors that mediate cell-cell or cell-matrix adhesion. They are transmembrane heterodimers composed of alpha and beta subunits and are connected to the cytoskeleton. At least 20 integrins, formed from combinations of 12 alpha and 9 beta subunits, have been reported. Many of these have been implicated as transducers of molecular signals. The integrin alpha5 subunit is 1049 amino acids with a molecular weight of 150-165 kDa. alpha5 and beta1 form a functional fibronectin receptor which is important for vascular development in mice. Both subunits of the fibronectin receptor are heavily glycosylated in their extracellular domains. This modification is essential for proper cell attachment to basal membranes. Integrin alpha5 has been reported to suppress apoptosis by a Bcl-2 pathway and the C-terminal region is critical for cell motility and cytoskeletal rearrangements. This antibody is routinely tested by western blot analysis.
Synonyms: Integrin alpha5 -
分子量
- 150 kDa
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途径
- Integrin Complex
抗原
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