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JAK1 抗体 (AA 551-766)

Name: JAK1 抗体 (AA 551-766)
SKU: ABIN967842
Availability: OutOfStock

This anti-JAK1 antibody is a 小鼠单克隆 antibody detecting JAK1 in WB, IHC, IP 和 IF. Suitable for 人, 小鼠, 大鼠, 小鸡, 犬和 Frog. This Primary Antibody has been cited in 4+ publications.

Western blot analysis of JAK1 on Jurkat cell lysate. (JAK1 抗体 (AA 551-766))

Image no. 1 for anti-Janus Kinase 1 (JAK1) (AA 551-766) antibody (ABIN967842) (JAK1 抗体 (AA 551-766))

Immunofluorescent staining of Human Endothelial cells. (JAK1 抗体 (AA 551-766))

3 images

(4 references)

产品编号 ABIN967842

发货至: 中国

Quick Overview for JAK1 抗体 (AA 551-766) (ABIN967842)

抗原

See all JAK1 抗体

JAK1 (Janus Kinase 1 (JAK1))

适用

人, 小鼠, 大鼠, 小鸡, 犬, Frog

宿主

小鼠

克隆类型

单克隆

标记

This JAK1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

克隆位点

73-JAK1

Discover our top product JAK1 Primary Antibody

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AA 551-766

交叉反应

犬, 大鼠, 小鼠, 小鸡, Frog

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
5. For fluorochrome spectra and suitable instrument settings, please refer to us.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human JAK1 aa. 551-766

亚型

IgG1 kappa
anti-Janus Kinase 1 (JAK1) (pTyr1022), (pTyr1023) antibody
JAK1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Janus Kinase 1 (JAK1) (pTyr1022) antibody
JAK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF 宿主: 兔 Polyclonal unconjugated

anti-Janus Kinase 1 (JAK1) (AA 960-1040) antibody
JAK1 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal unconjugated

anti-Janus Kinase 1 (JAK1) (AA 1020-1024) antibody
JAK1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Janus Kinase 1 (JAK1) antibody
JAK1 适用: 人, 大鼠 WB, IP 宿主: 小鼠 Monoclonal 7B1-B6-G7 unconjugated

anti-Janus Kinase 1 (JAK1) (AA 172-204), (N-Term) antibody
JAK1 适用: 人 WB 宿主: 兔 Polyclonal RB43809 unconjugated

anti-Janus Kinase 1 (JAK1) (AA 866-899), (C-Term) antibody
JAK1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB43812 unconjugated

anti-Janus Kinase 1 (JAK1) (Ser639) antibody
JAK1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Janus Kinase 1 (JAK1) (C-Term) antibody
JAK1 适用: 人, 小鼠, 大鼠, 小鸡, 犬, Cow, Pig WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated

anti-Janus Kinase 1 (JAK1) (pTyr1034), (pTyr1035) antibody
JAK1 适用: 人, 小鼠 WB, ELISA, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated

说明

Related Products: ABIN968537, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20°C.
Kopantzev, Heller, Swaminathan, Rudikoff: "IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells." in: Oncogene, Vol. 21, Issue 44, pp. 6791-800, (2002) (PubMed).

Blesofsky, Mowen, Arduini, Baker, Murphy, Bowtell, David: "Regulation of STAT protein synthesis by c-Cbl." in: Oncogene, Vol. 20, Issue 50, pp. 7326-33, (2001) (PubMed).

Kawazoe, Naka, Fujimoto, Kohzaki, Morita, Narazaki, Okumura, Saitoh, Nakagawa, Uchiyama, Akira, Kishimoto: "Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation." in: The Journal of experimental medicine, Vol. 193, Issue 2, pp. 263-9, (2001) (PubMed).

Müller, Briscoe, Laxton, Guschin, Ziemiecki, Silvennoinen, Harpur, Barbieri, Witthuhn, Schindler: "The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction." in: Nature, Vol. 366, Issue 6451, pp. 129-35, (1993) (PubMed).
抗原

JAK1 (Janus Kinase 1 (JAK1))

别名

JAK1

背景

The JAK family of receptor-associated protein kinases is directly involved in interferon (IFN) response pathways. The JAK family contains at least three members: JAK1, JAK2, and Tyk2. Each protein is approximately 130 kDa and contains a C-terminal tyrosine kinase domain, an adjacent kinase or kinase-related domain, and five other domains that are highly conserved among family members. In several human and murine cell lines, JAK1 is rapidly tyrosine phosphorylated in response to IFN-alpha and IFN-gamma. JAK1 is required for the phosphorylation of the transcription factor Stat1 (p91), in response to IFNs-alpha or IFN-gamma. JAK1 is also necessary for the efficient phophorylation of Stat2 (p113) in response to IFN-alpha and for the phosphorylation of Tyk2 or JAK2 in response to IFNs-alpha or IFN-gamma, respectively.

分子量

130 kDa

途径

JAK/STAT Signaling, RTK signaling, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded Protein Response