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EGFR 抗体 (AA 1020-1046)

EGFR 适用: 人, 小鼠 WB, IHC, IF, FACS, IP 宿主: 小鼠 Monoclonal 13-EGFR unconjugated
产品编号 ABIN967697
发货至: 中国
  • 抗原 See all EGFR 抗体
    EGFR (Epidermal Growth Factor Receptor (EGFR))
    抗原表位
    • 41
    • 39
    • 39
    • 38
    • 35
    • 28
    • 27
    • 27
    • 22
    • 21
    • 19
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    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    AA 1020-1046
    适用
    • 821
    • 327
    • 317
    • 26
    • 26
    • 24
    • 20
    • 15
    • 9
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 650
    • 174
    • 14
    • 11
    • 5
    • 1
    小鼠
    克隆类型
    • 598
    • 252
    • 2
    单克隆
    标记
    • 430
    • 65
    • 33
    • 30
    • 29
    • 29
    • 29
    • 27
    • 27
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    • 23
    • 17
    • 10
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    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This EGFR antibody is un-conjugated
    应用范围
    • 578
    • 262
    • 146
    • 144
    • 137
    • 101
    • 101
    • 96
    • 81
    • 55
    • 37
    • 34
    • 34
    • 18
    • 10
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    • 4
    • 4
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    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunoprecipitation (IP)
    交叉反应
    小鼠
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human EGF Receptor aa. 1020-1046
    克隆位点
    13-EGFR
    亚型
    IgG1
    Top Product
    Discover our top product EGFR Primary Antibody
  • 说明

    Related Products: ABIN968533, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Deugnier, Faraldo, Janji, Rousselle, Thiery, Glukhova: "EGF controls the in vivo developmental potential of a mammary epithelial cell line possessing progenitor properties." in: The Journal of cell biology, Vol. 159, Issue 3, pp. 453-63, (2002) (PubMed).

    Golubovskaya, Beviglia, Xu, Earp, Craven, Cance: "Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells." in: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38978-87, (2002) (PubMed).

    Ford, Valle, Soroka, Merchant: "EGF receptor activation stimulates endogenous gastrin gene expression in canine G cells and human gastric cell cultures." in: The Journal of clinical investigation, Vol. 99, Issue 11, pp. 2762-71, (1997) (PubMed).

    Kizaka-Kondoh, Matsuda, Okayama: "CrkII signals from epidermal growth factor receptor to Ras." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 22, pp. 12177-82, (1996) (PubMed).

    Ward, Gough, Rashke, Wan, Tribbick, Wang: "Systematic mapping of potential binding sites for Shc and Grb2 SH2 domains on insulin receptor substrate-1 and the receptors for insulin, epidermal growth factor, platelet-derived growth factor, and fibroblast growth factor." in: The Journal of biological chemistry, Vol. 271, Issue 10, pp. 5603-9, (1996) (PubMed).

  • 抗原
    EGFR (Epidermal Growth Factor Receptor (EGFR))
    别名
    EGF Receptor (EGFR 产品)
    别名
    C-erb antibody, CG10079 antibody, D-EGFR antibody, D-Egf antibody, DEGFR antibody, DER antibody, DER flb antibody, DER/EGFR antibody, DER/faint little ball antibody, DER/top antibody, DER/torpedo antibody, DER1 antibody, DEgfr antibody, Degfr antibody, Der antibody, DmHD-33 antibody, Dmel\\CG10079 antibody, EFG-R antibody, EGF-R antibody, EGFR antibody, EGFr antibody, EGfr antibody, EK2-6 antibody, Egf antibody, Egf-r antibody, EgfR antibody, El antibody, Elp antibody, Elp-1 antibody, Elp-B1 antibody, Elp-B1RB1 antibody, HD-33 antibody, TOP antibody, Torpedo/DER antibody, Torpedo/Egfr antibody, c-erbB antibody, d-egf-r antibody, dEGFR antibody, dEGFR1 antibody, dEgfr antibody, der antibody, egfr antibody, flb antibody, l(2)05351 antibody, l(2)09261 antibody, l(2)57DEFa antibody, l(2)57EFa antibody, l(2)57Ea antibody, mor1 antibody, top antibody, top/DER antibody, top/flb antibody, torpedo/Egfr antibody, torpedo/egfr antibody, EGFR12 antibody, EGFR15 antibody, egfr1 antibody, Erbb2 antibody, ERBB antibody, ERBB1 antibody, HER1 antibody, PIG61 antibody, mENA antibody, ErbB-1 antibody, Errp antibody, 9030024J15Rik antibody, AI552599 antibody, Erbb antibody, Errb1 antibody, Wa5 antibody, wa-2 antibody, wa2 antibody, epidermal growth factor receptor antibody, Epidermal growth factor receptor antibody, epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) antibody, EGFR antibody, Egfr antibody, egfra antibody, egfr1 antibody, LOC5564544 antibody
    背景
    Epidermal Growth Factor (EGF) elicits a variety of cellular responses that are initiated by EGF receptor (EGF-R) binding and activation of intrinsic tyrosine kinase activity. Following ligand binding, EGF receptor is autophosphorylated and, in turn, phosphorylates several other endogenous proteins including phospholipase Cgamma. These events initiate a number of intracellular responses that include increased levels of intracellular Ca2+ and transient expression of the nuclear oncogene products c-Myc and c-Fos. This antibody is routinely tested by western blot analysis.
    分子量
    180 kDa
    途径
    NF-kappaB Signaling, RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteins
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