我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

SYK 抗体 (C-Term)

Name: SYK 抗体 (C-Term)
Brand: antibodies-online
SKU: ABIN967119
Availability: OutOfStock

Cited in 6+ publications. The 兔多克隆 anti-SYK antibody (ABIN967119) specifically detects SYK in IHC. The antibody is reactive with 人和小鼠 samples.

(6 references)

产品编号 ABIN967119

发货至: 中国

Contact our Customer Service for availability and price in your country. Contact Info

Our Local Distributor

中国
北京 101111

No. 88 KeChuang 6th Street

Beijing Economic Technological Development Area

Room 801-803

4A Biotech Co.,Ltd.

Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for SYK 抗体 (C-Term) (ABIN967119)

抗原

See all SYK 抗体

SYK (Spleen tyrosine Kinase (SYK))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This SYK antibody is un-conjugated

应用范围

Immunohistochemistry (IHC)

Discover our top product SYK Primary Antibody

抗原表位
36

30

20

14

11

8

8

8

5

4

4

4

3

3

3

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term

免疫原

Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human SYK (Tyrosine-protein kinase SYK)
anti-Spleen tyrosine Kinase (SYK) (AA 5-360) antibody
SYK 适用: 人, 小鼠, 大鼠 WB, IHC (p), IP, ICC 宿主: 小鼠 Monoclonal SYK-01 unconjugated

anti-Spleen tyrosine Kinase (SYK) (pTyr323) antibody
SYK 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Spleen tyrosine Kinase (SYK) (pTyr348) antibody
SYK 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Spleen tyrosine Kinase (SYK) (pTyr525) antibody
SYK 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Spleen tyrosine Kinase (SYK) (Internal Region) antibody
SYK 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Spleen tyrosine Kinase (SYK) (AA 217-356) antibody
SYK 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 2G11E6 unconjugated

anti-Spleen tyrosine Kinase (SYK) (AA 217-356) antibody
SYK 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 3D1G10 unconjugated

anti-Spleen tyrosine Kinase (SYK) (AA 387-417), (C-Term) antibody
SYK 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB03097 unconjugated

anti-Spleen tyrosine Kinase (SYK) (pTyr525), (pTyr526) antibody
SYK 适用: 人, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Spleen tyrosine Kinase (SYK) (pTyr323) antibody
SYK 适用: 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

限制

仅限研究用
储存条件

4 °C
Salomon, Ficarro, Brill, Brinker, Phung, Ericson, Sauer, Brock, Horn, Schultz, Peters: "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 2, pp. 443-8, (2003) (PubMed).

Xu, Zhao, Zhao: "Molecular cloning and characterization of SPAP1, an inhibitory receptor." in: Biochemical and biophysical research communications, Vol. 280, Issue 3, pp. 768-75, (2001) (PubMed).

Tang, Sawasdikosol, Chang, Burakoff: "SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 17, pp. 9775-80, (1999) (PubMed).

Deckert, Elly, Altman, Liu: "Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases." in: The Journal of biological chemistry, Vol. 273, Issue 15, pp. 8867-74, (1998) (PubMed).

Yagi, Suzuki, Hasegawa, Okumura, Ra: "Cloning of the cDNA for the deleted syk kinase homologous to ZAP-70 from human basophilic leukemia cell line (KU812)." in: Biochemical and biophysical research communications, Vol. 200, Issue 1, pp. 28-34, (1994) (PubMed).

Law, Sidorenko, Chandran, Draves, Chan, Weiss, Edelhoff, Disteche, Clark: "Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex." in: The Journal of biological chemistry, Vol. 269, Issue 16, pp. 12310-9, (1994) (PubMed).
抗原

SYK (Spleen tyrosine Kinase (SYK))

别名

SYK

背景

SYK (Tyrosine-protein kinase SYK) is a positive effector of BCR-stimulated responses. SYK couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion. SYK interacts with CBL and SLA when it is phosphorylated. The interaction with SLA may link it to CBL, leading to its destruction. SYK interacts with phosphorylated NFAM1. SYK interacts with Epstein-Barr virus LMP2A. SYK interacts through its SH2 domains with the phosphorylated ITAM domain of CD79A which stimulates SYK autophosphorylation and activation. SYK interacts with FCRL3. Phosphorylation on Tyr-323 creates a binding site for c-Cbl, an adapter protein that serves as a negative regulator of BCR-stimulated calcium ion signaling. Phosphorylation on Tyr-348 and Tyr-352 enhances the phosphorylation and activation of phospholipase C-gamma and the early phase of calcium ion mobilization via a phosphoinositide 3-kinase-independent pathway. Ubiquitinated by CBLB after BCR activation, which promotes proteasomal degradation. SYK belongs to the protein kinase superfamily, Tyr protein kinase family and SYK/ZAP-70 subfamily.

途径

Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling