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SYK 抗体 (AA 5-360)

SYK 适用: 人, 小鼠, 大鼠 WB, IHC (p), IP, ICC 宿主: 小鼠 Monoclonal SYK-01 unconjugated
产品编号 ABIN94475
发货至: 中国
  • 抗原 See all SYK 抗体
    SYK (Spleen tyrosine Kinase (SYK))
    抗原表位
    • 29
    • 22
    • 20
    • 13
    • 10
    • 10
    • 8
    • 8
    • 8
    • 7
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 5-360
    适用
    • 169
    • 81
    • 50
    • 11
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 158
    • 14
    • 3
    小鼠
    克隆类型
    • 161
    • 13
    单克隆
    标记
    • 101
    • 12
    • 10
    • 8
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    This SYK antibody is un-conjugated
    应用范围
    • 146
    • 84
    • 46
    • 25
    • 22
    • 19
    • 14
    • 14
    • 12
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    特异性
    The antibody SYK-01 reacts with protein tyrosine kinase p72Syk (Syk, an intracellular antigen), which is required for the transduction of signals through the B cell antigen receptor (BCR) and the high affinity IgE receptor (FcepsilonRI).
    交叉反应 (详细)
    Mouse, Human, Rat, Other not tested
    纯化方法
    Purified by protein-A affinity chromatography.
    纯度
    > 95 % (by SDS-PAGE)
    免疫原
    Recombinant fragment (aa 5-360) of human Syk.
    克隆位点
    SYK-01
    亚型
    IgG1
  • 应用备注
    Western blotting: Recommended dilution: 1-2 μg/mL.
    Immunohistochemistry (paraffin sections): Recommended dilution: 5 μg/mL, positive tissue: tonsil B cells.
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Do not freeze.
  • Hasan, Rahman, Sebo, Osicka: "Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling." in: Toxins, Vol. 11, Issue 6, (2020) (PubMed).

    Heneberg, Lebduska, Dráberová, Korb, Dráber: "Topography of plasma membrane microdomains and its consequences for mast cell signaling." in: European journal of immunology, Vol. 36, Issue 10, pp. 2795-806, (2006) (PubMed).

    Hálová, Dráberová, Dráber: "A novel lipid raft-associated glycoprotein, TEC-21, activates rat basophilic leukemia cells independently of the type 1 Fc epsilon receptor." in: International immunology, Vol. 14, Issue 2, pp. 213-23, (2002) (PubMed).

    Arudchandran, Brown, Peirce, Song, Zhang, Siraganian, Blank, Rivera: "The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1." in: The Journal of experimental medicine, Vol. 191, Issue 1, pp. 47-60, (2000) (PubMed).

  • 抗原
    SYK (Spleen tyrosine Kinase (SYK))
    别名
    Syk (SYK 产品)
    别名
    p72-Syk antibody, Sykb antibody, p72syk antibody, spleen associated tyrosine kinase antibody, spleen tyrosine kinase antibody, syk antibody, SYK antibody, Syk antibody
    背景
    Spleen associated tyrosine kinase,Syk is a cytoplasmic protein tyrosine kinase that translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.,p72Syk
    基因ID
    6850
    UniProt
    P43405
    途径
    Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling
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