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POLB 抗体 (N-Term)

This anti-POLB antibody is a 兔 多克隆 antibody detecting POLB in IHC. Suitable for 人, 小鼠 和 大鼠. This Primary Antibody has been cited in 9+ publications.
产品编号 ABIN966876
发货至: 中国

Quick Overview for POLB 抗体 (N-Term) (ABIN966876)

抗原

See all POLB 抗体
POLB (Polymerase (DNA Directed), beta (POLB))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This POLB antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC)
  • 抗原表位

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    N-Term

    免疫原

    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human POLB (DNA polymerase beta)
  • 限制

    仅限研究用
  • 储存条件

    4 °C
  • El-Andaloussi, Valovka, Toueille, Steinacher, Focke, Gehrig, Covic, Hassa, Schär, Hübscher, Hottiger: "Arginine methylation regulates DNA polymerase beta." in: Molecular cell, Vol. 22, Issue 1, pp. 51-62, (2006) (PubMed).

    DeMott, Beyret, Wong, Bales, Hwang, Greenberg, Demple: "Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone." in: The Journal of biological chemistry, Vol. 277, Issue 10, pp. 7637-40, (2002) (PubMed).

    Patterson, Little, Cheng, Widen, Kumar, Beard, Wilson: "Molecular cloning and high-level expression of human polymerase beta cDNA and comparison of the purified recombinant human and rat enzymes." in: Protein expression and purification, Vol. 18, Issue 1, pp. 100-10, (2000) (PubMed).

    Matsumoto, Kim, Katz, Feng: "Catalytic center of DNA polymerase beta for excision of deoxyribose phosphate groups." in: Biochemistry, Vol. 37, Issue 18, pp. 6456-64, (1998) (PubMed).

    Dobashi, Kubota, Shuin, Torigoe, Yao, Hosaka: "Polymorphisms in the human DNA polymerase beta gene." in: Human genetics, Vol. 95, Issue 4, pp. 389-90, (1995) (PubMed).

    Chyan, Ackerman, Shepherd, McBride, Widen, Wilson, Wood: "The human DNA polymerase beta gene structure. Evidence of alternative splicing in gene expression." in: Nucleic acids research, Vol. 22, Issue 14, pp. 2719-25, (1994) (PubMed).

    Widen, Kedar, Wilson: "Human beta-polymerase gene. Structure of the 5'-flanking region and active promoter." in: The Journal of biological chemistry, Vol. 263, Issue 32, pp. 16992-8, (1988) (PubMed).

    Abbotts, SenGupta, Zmudzka, Widen, Notario, Wilson: "Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme." in: Biochemistry, Vol. 27, Issue 3, pp. 901-9, (1988) (PubMed).

    SenGupta, Zmudzka, Kumar, Cobianchi, Skowronski, Wilson: "Sequence of human DNA polymerase beta mRNA obtained through cDNA cloning." in: Biochemical and biophysical research communications, Vol. 136, Issue 1, pp. 341-7, (1986) (PubMed).

  • 抗原

    POLB (Polymerase (DNA Directed), beta (POLB))

    别名

    POLB

    背景

    POLB (DNA polymerase beta) is a repair polymerase. POLB conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. POLB has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. POLB binds 2 magnesium ions per subunit (By similarity).POLB belongs to the DNA polymerase type-X family.

    途径

    DNA Damage Repair
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