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NOTCH3 抗体 (N-Term)

This anti-NOTCH3 antibody is a 兔 多克隆 antibody detecting NOTCH3 in IHC. Suitable for 人. This Primary Antibody has been cited in 3+ publications.
产品编号 ABIN966685
发货至: 中国

Quick Overview for NOTCH3 抗体 (N-Term) (ABIN966685)

抗原

See all NOTCH3 抗体
NOTCH3 (Notch 3 (NOTCH3))

适用

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宿主

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克隆类型

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多克隆

标记

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This NOTCH3 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC)
  • 抗原表位

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    N-Term

    免疫原

    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to very N-terminal residues of human NOTCH3 (Neurogenic locus notch homolog protein 3)
  • 限制

    仅限研究用
  • 储存条件

    4 °C
  • Wu, Sun, Kobayashi, Gao, Griffin: "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors." in: Molecular and cellular biology, Vol. 22, Issue 21, pp. 7688-700, (2002) (PubMed).

    Gray, Mann, Mitsiadis, Henrique, Carcangiu, Banks, Leiman, Ward, Ish-Horowitz, Artavanis-Tsakonas: "Human ligands of the Notch receptor." in: The American journal of pathology, Vol. 154, Issue 3, pp. 785-94, (1999) (PubMed).

    Joutel, Corpechot, Ducros, Vahedi, Chabriat, Mouton, Alamowitch, Domenga, Cécillion, Marechal, Maciazek, Vayssiere, Cruaud, Cabanis, Ruchoux, Weissenbach, Bach, Bousser, Tournier-Lasserve: "Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia." in: Nature, Vol. 383, Issue 6602, pp. 707-10, (1996) (PubMed).

  • 抗原

    NOTCH3 (Notch 3 (NOTCH3))

    别名

    NOTCH3

    背景

    NOTCH3 (Neurogenic locus notch homolog protein 3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. NOTCH3 affects the implementation of differentiation, proliferation and apoptotic programs. NOTCH3 is a heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds. NOTCH3 interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH3. NOTCH3 is ubiquitously expressed in fetal and adult tissues. It is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane. Defects in NOTCH3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). CADASIL causes a type of stroke and dementia of which key features include recurrent subcortical ischemic events and vascular dementia. The disorder affects relatively young adults of both sexes.

    途径

    Notch Signaling
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